Research Topic · Peer-Reviewed

Prosthetic Groups

Prosthetic groups are essential components of many biological molecules, including enzymes and other proteins. These small, highly specialized molecules play critical roles in the structure, function and regulation of biological systems. In chemistry, prosthetic groups are often referred to as co-factors, and are de…

Curated from this journal's research 📚 1 peer-reviewed article cited Cited 4× across the literature 🔖 ISSN 2377-2549 🗓 Reviewed June 2026

Overview

Prosthetic groups are essential components of many biological molecules, including enzymes and other proteins. These small, highly specialized molecules play critical roles in the structure, function and regulation of biological systems. In chemistry, prosthetic groups are often referred to as co-factors, and are defined as non-protein molecules that are required for the biological activity of enzymes. Prosthetic groups provide enzymes with the necessary functional groups, such as metal ions or complex organic molecules, that enable them to catalyze specific chemical reactions. For example, heme is a prosthetic group found in many proteins, including hemoglobin, an oxygen-carrying protein in red blood cells. The iron-containing heme group allows hemoglobin to bind to oxygen, ultimately enabling the transport of oxygen throughout the body. In addition to enabling enzyme activity, prosthetic groups can also play important roles in regulating enzyme function. For example, regulatory proteins may bind to specific prosthetic groups on an enzyme, altering the enzyme’s activity. This is commonly seen in the regulation of metabolic pathways, where multiple enzymes work together to catalyze a series of chemical reactions. Overall, prosthetic groups are critical to many biological processes, including metabolism, signal transduction, and DNA repair. Understanding the structures and functions of these groups is essential to advancing our understanding of the chemical and biological processes that govern life. As such, research into the chemistry of prosthetic groups is an active area of study in many fields, including biochemistry, chemical biology and medicinal chemistry.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

How this research is being cited

The 1 article above has been cited 4 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Prosthetic Groups, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Annarita Del Gatto · Italy Bharat Gurale · United States Palani ELUMALAI · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.