Potentiometric Titration

Potentiometric titration is a powerful analytical technique used in chemistry to determine the concentration of an analyte (a substance being analyzed) in a solution by measuring the potential difference between electrodes immersed in the solution. The technique relies on the use of an indicator that generates an electrical signal, which is directly proportional to the concentration of the analyte being measured. Potentiometric titrations use an electrometric sensor or electrode to measure the potential difference between two electrodes in a solution. The analyte, which is usually dissolved in a solvent, is added to a solution that contains an electrolyte of known concentration. The concentration of the electrolyte is then gradually increased or decreased, depending on the type of titration being performed. As the concentration of the analyte increases, the potential difference between the two electrodes changes, leading to a shift in the electrode reaction. The technique is highly sensitive and precise, making it a popular choice in many areas of chemistry, such as pharmaceuticals and food analysis. It is also widely used in the study of proteins, nucleic acids, and other biomolecules where it is used to determine the concentration of ions, pH, and other properties. Potentiometric titration is an effective analytical tool that can provide a wealth of information about the composition and properties of a solution. With continuing research and advancements in technology, potentiometric titration remains a critical tool in the ongoing quest for more accurate and efficient methods for chemical analysis.


From: Journal of New Developments in Chemistry

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Editor-in-chief: Zhe-Sheng Chen, Professor Department of Pharmaceutical Sciences College of Pharmacy and Allied Health Professions St. John’s University
Publication Type: Open Access Journal
Description: Chemistry is a branch of physical science that studies the composition, structure, properties and change of matter. Chemistry includes topics such as the properties of individual atoms, how atoms form chemical bonds to create chemical compounds, the interactions of substances through inter molecular forces that give matter its general properties.