Research Topic · Peer-Reviewed

Ion Exchange Chromatography

Ion Exchange Chromatography is a widely used method in the field of chemistry that separates the ionic and polar molecules based on their charge. This methodology functions via the use of resin-packed columns and typically eluted by salt gradients. In this method, the negatively or positively charged molecules are s…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 34× across the literature 🔖 ISSN 2377-2549 🗓 Reviewed June 2026

Overview

Ion Exchange Chromatography is a widely used method in the field of chemistry that separates the ionic and polar molecules based on their charge. This methodology functions via the use of resin-packed columns and typically eluted by salt gradients. In this method, the negatively or positively charged molecules are separated from the neutral molecules based on the affinity of the molecule to the resin. The charged molecule is either attracted or repelled by the resin and thus gets separated from the other molecules. Ion exchange chromatography is beneficial in various chemical industries, such as pharmaceuticals, food, and biotech because it is a cost-effective and straightforward method with a high specificity and selectivity. With advancements in technology, new resin materials with a range of ion exchange properties have been designed for better resolution, selectivity and speed. Recent developments in this field have led to the introduction of advanced ion exchange chromatography techniques like electrostatic ion chromatography, which uses charged solutes and Electrostatic Rayleigh Scattering Detector (ERSD) for better resolution and detection. Overall, Ion Exchange Chromatography has proved to be a versatile method for the analysis and separation of polar and ionic molecules. It is a cost-effective, efficient and easy-to-perform method which has made it an essential part of the analytical chemistry field in protein separations, DNA purification, and analysis of small molecules.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Ion Exchange Chromatography, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Annarita Del Gatto · Italy Bharat Gurale · United States Palani ELUMALAI · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.