Research Topic · Peer-Reviewed

Transient Receptor Potential Channels

Transient receptor potential channels are a superfamily of nonselective cation channels that play critical roles in cellular signaling by allowing the passage of calcium and other ions across cell membranes in response to diverse stimuli including temperature, pH, mechanical stress, and chemical ligands. Research pu…

Curated from this journal's research 📚 1 peer-reviewed article cited Cited 4× across the literature 🔖 ISSN 2470-5020

Overview

Transient receptor potential channels are a superfamily of nonselective cation channels that play critical roles in cellular signaling by allowing the passage of calcium and other ions across cell membranes in response to diverse stimuli including temperature, pH, mechanical stress, and chemical ligands. Research published in Neurological Research and Therapy has examined calcium channel dysfunction in the context of neuromuscular disorders, specifically investigating how mutations affecting channel properties contribute to disease pathophysiology. One study explored a skeletal muscle calcium channel mutation that altered channel inactivation kinetics and produced abnormal omega-currents during hyperpolarization, mechanisms that were shown to contribute to hypokalemic periodic paralysis, a condition characterized by episodes of severe muscle weakness associated with low blood potassium levels. This work illustrates the broader significance of understanding ion channel biophysics in neurological and neuromuscular conditions, as even subtle changes in channel gating, inactivation, or ionic selectivity can profoundly impact muscle excitability and function. Elucidating these molecular mechanisms provides essential insights into disease processes and may inform the development of targeted therapeutic approaches for channelopathies affecting the nervous system and skeletal muscle.

Research published in this journal

1 peer-reviewed article, ranked by relevance. Each links to its DOI.

How this research is being cited

The 1 article above has been cited 4 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Transient Receptor Potential Channels, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Neurological Research and Therapy (ISSN 2470-5020).

Journal editorial board
Zheng Jiang · United States Giuseppe Lanza · Italy Asuman Celikbilek · Turkey

This page summarises published research for orientation; it is not medical or professional advice.