Research Topic · Peer-Reviewed

Transcription Factors

Transcription factors are regulatory proteins that bind specific DNA sequences and control the rate at which genetic information is transcribed from DNA into messenger RNA, thereby governing gene expression. Each typically contains a DNA-binding domain that recognises short consensus motifs within promoters and enha…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 70× across the literature 🔖 ISSN 2470-5020 🗓 Reviewed June 2026

Overview

Transcription factors are regulatory proteins that bind specific DNA sequences and control the rate at which genetic information is transcribed from DNA into messenger RNA, thereby governing gene expression. Each typically contains a DNA-binding domain that recognises short consensus motifs within promoters and enhancers, together with activation or repression domains that recruit coactivators, corepressors, and the basal transcriptional machinery. By integrating intracellular and extracellular signals, transcription factors orchestrate cell-fate determination, differentiation, proliferation, and adaptive responses to stress. In the nervous system they direct neurogenesis, gliogenesis, and the maturation of oligodendrocytes, including their regulation through signalling cascades such as the Wnt pathway, and their dysregulation contributes to neurodegenerative and proliferative disease. Computational analyses of regulatory single-nucleotide polymorphisms and predicted transcription-factor binding sites illustrate how sequence variation can alter promoter occupancy and disease susceptibility, while families such as transcription factor EB link these proteins to inflammatory signalling and pathway control. Related research extends to embryonic developmental programmes, plant DNA-binding factors whose dimerisation depends on disulfide bonds, and the interplay of transcription factors with kinases and chemokine regulation. The journal publishes peer-reviewed studies addressing transcriptional regulation, gene-expression control, and its relevance to neurological and biomedical research.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 70 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Transcription Factors, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Neurological Research and Therapy (ISSN 2470-5020).

Journal editorial board
Ian J Martins · Australia Giuseppe Lanza · Italy Ion Codreanu · United States

This page summarises published research for orientation; it is not medical or professional advice.