Septate Junctions

Septate junctions are specialized structures found in the nervous system that are essential for maintaining the integrity of the blood-brain barrier. These junctions form a physical barrier between adjacent cells in the central nervous system, which helps to prevent the uncontrolled flow of ions and molecules between cells. Studies have shown that septate junctions are involved in a wide range of neurological processes, including synaptic function, plasticity, and learning and memory. Defects in these structures have also been linked to a number of neurological disorders, including Alzheimer's disease and multiple sclerosis. In recent years, researchers have focused on developing new therapies targeting septate junctions to treat these and other neurological disorders. One promising approach involves the use of biologics that target specific proteins involved in forming the junctions. These biologics have demonstrated the potential to improve cognitive function and reverse the effects of neurological disorders in preclinical studies. Overall, the study of septate junctions has provided valuable insights into the mechanisms of neurological function and dysfunction. By continuing to explore these structures and their role in neurological disorders, researchers may be able to develop more effective therapies for these debilitating conditions.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.