Peripherin is a protein that is primarily found in the peripheral nervous system (PNS). It is a type III intermediate filament protein that plays a critical role in the development and maintenance of PNS neurons. Peripherin is expressed during the early stages of neuronal differentiation and plays a crucial role in determining the fate of neuronal precursor cells. Aberrant expression or mutations of the Peripherin gene have been implicated in the development of peripheral neuropathies and other neurological disorders. Recent research in the field of neuroscience has investigated the use of Peripherin as a potential therapeutic target for the treatment of neurological disorders. Studies have shown that Peripherin levels are upregulated in response to neuronal injury or disease. Therefore, targeting Peripherin could represent a promising therapeutic strategy for the treatment of disorders such as peripheral neuropathy, amyotrophic lateral sclerosis (ALS), and spinal cord injury. In addition to its potential therapeutic applications, Peripherin has also been used as a marker for distinguishing between different types of PNS neurons. This has led to advancements in the classification and understanding of PNS neuropathies and has the potential to improve patient outcomes through more accurate diagnosis and treatment. In summary, Peripherin represents an important protein in the development and maintenance of the peripheral nervous system. Its potential as a therapeutic target and its use as a marker for classifying PNS neuropathies highlights the importance of continued research in the field of neuroscience.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.