Peripherin is an intermediate filament protein predominantly expressed in neurons of the peripheral nervous system, where it plays a structural role in maintaining axonal integrity and supporting neuronal function. Research published in Neurological Research and Therapy has examined peripherin in the context of prot…
Peripherin is an intermediate filament protein predominantly expressed in neurons of the peripheral nervous system, where it plays a structural role in maintaining axonal integrity and supporting neuronal function. Research published in Neurological Research and Therapy has examined peripherin in the context of proteomic responses to therapeutic interventions, specifically investigating how treatment with lapatinib, a tyrosine kinase inhibitor, affects protein expression patterns. Using ion-current-based proteomics methodology, investigators have characterized changes in peripherin levels as part of comprehensive analyses of cellular protein responses to targeted drug treatments. This work contributes to understanding how pharmacological agents influence the expression of structural proteins in neural and other cell types, which has implications for both therapeutic efficacy and potential neurotoxicity. The study of peripherin expression changes following drug exposure is relevant to neurology because alterations in intermediate filament proteins can affect neuronal stability and function, and may serve as biomarkers for cellular stress or adaptation. Such proteomic investigations help elucidate the broader molecular consequences of targeted therapies and inform the development of treatment strategies that minimize adverse effects on neuronal structural integrity.
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The 1 article above has been cited 3 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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