Odontoblasts are specialized cells that are found in the dental pulp of teeth. These cells play a crucial role in the formation and maintenance of dentin, which is the hard, calcified tissue that makes up the bulk of our teeth. When a tooth is damaged or decayed, odontoblasts are activated and begin producing new dentin to repair the damage. This process is known as reparative dentinogenesis and is essential for maintaining the structural integrity of our teeth. In addition to their role in dentin formation, recent research has shown that odontoblasts may also play a role in regulating pain in the teeth. This is because these cells have been shown to produce and release a number of different signaling molecules, including nerve growth factors and neurotransmitters. These signaling molecules are thought to play a role in modulating the sensitivity of the dental pulp to various stimuli, such as changes in temperature or pressure. By regulating these signals, odontoblasts may be able to help reduce the sensation of pain in the teeth. Overall, the study of odontoblasts in dental research has led to a better understanding of the mechanisms underlying dental damage and repair, as well as the regulation of pain in the teeth. This research may ultimately lead to new therapies and treatments for a range of dental conditions, including cavities, tooth decay, and sensitivity.

From: Neurobiology

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