Nestin

Nestin is a type of protein that plays a crucial role in the development and maintenance of the nervous system. It is primarily expressed in neural stem cells and progenitor cells, which are responsible for generating new neurons and other cells in the brain and spinal cord. Research has shown that nestin is a promising target for neurological therapies aimed at promoting neuroplasticity, regeneration, and repair of the nervous system. This is because nestin-positive cells have the ability to differentiate into multiple neural cell types, including neurons and glial cells, and can even migrate to damaged regions to promote repair. In addition to its roles in development and repair, nestin has also been implicated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Studies have shown that levels of nestin are altered in the brains of individuals with these conditions, suggesting that it may play a role in the pathogenesis and progression of these diseases. In terms of therapy, there are several approaches being explored to target nestin for neurological disorders. One strategy involves using small molecules or peptides to activate nestin-positive cells and promote their proliferation and differentiation into neurons and glial cells. Another approach involves directly targeting nestin itself, either by blocking its expression or inhibiting its activity, to prevent or slow the progression of neurodegenerative diseases. Overall, nestin holds great promise as a therapeutic target in the field of neurological research and therapy, and further studies are needed to fully understand its complex role in the nervous system.


From: Journal of Neurological Research And Therapy

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.