Nerve agent hydrolysis is the chemical breakdown of nerve agents through reaction with water, a process that converts these highly toxic compounds into less harmful products. Nerve agents are organophosphorus chemicals that disrupt the nervous system by inhibiting acetylcholinesterase, an enzyme essential for normal…
Nerve agent hydrolysis is the chemical breakdown of nerve agents through reaction with water, a process that converts these highly toxic compounds into less harmful products. Nerve agents are organophosphorus chemicals that disrupt the nervous system by inhibiting acetylcholinesterase, an enzyme essential for normal nerve signaling, and exposure can cause seizures, respiratory failure, and death. Because of their toxicity, much research focuses on ways to neutralize them, and hydrolysis, whether spontaneous, catalyzed by enzymes, or promoted by engineered catalysts, is a key mechanism for detoxification and for developing medical and decontamination strategies. The study of how nerve agents are broken down and how their toxic effects on the nervous system can be countered is closely tied to neurology, where understanding cholinergic signaling and protecting neural function are central concerns. Neurological Research and Therapy publishes peer-reviewed, open-access work on the biology, disorders, and treatment of the nervous system. This page situates nerve agent hydrolysis within that broad scope, gathering material relevant to the chemistry of detoxification, the protection of nerve function, and the therapeutic approaches aimed at countering agents that act on the nervous system.
1 peer-reviewed article, ranked by relevance. Each links to its DOI.
The 1 article above has been cited 1 time in the scholarly literature. Citation data via OpenAlex and Crossref, updated Oct 2025.
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