Huntington Disease
Huntington Disease (HD) is a neurological disorder that causes the degeneration of brain cells, particularly in the basal ganglia and cortex regions. HD is an inherited disease that is caused by a mutation in the Huntingtin gene. This gene provides the instructions for making a protein called Huntingtin, which is involved in the normal function of nerve cells in the brain. The mutated Huntingtin protein causes damage to the nerve cells, leading to the symptoms of HD. The symptoms of HD typically appear in mid-life, between the ages of 30 and 50. Symptoms include involuntary movements, such as jerking or twisting movements of the limbs, face, and trunk, as well as difficulty with balance and coordination. As the disease progresses, cognitive and behavioral changes occur, including personality changes, depression, irritability, and anxiety. In advanced stages of HD, patients become unable to speak and require assistance with daily activities. While there is currently no cure for HD, there are treatments available to manage the symptoms of the disease. These treatments include medications to control involuntary movements and psychotherapy to manage the cognitive and behavioral changes that occur with the disease. Additionally, genetic testing is available for individuals who have a family history of HD or who are concerned about their risk for the disease. In summary, Huntington Disease is a debilitating neurological disorder that is caused by a genetic mutation. While there is no cure for the disease, there are treatments available to manage symptoms and genetic testing is available for individuals who are at risk for the disease. By continuing to research and develop treatments for HD, we can improve the lives of those affected by this devastating disease.
← Journal of Neurological Research And Therapy