Globus Pallidus

The Globus Pallidus is a neuroanatomical structure located in the basal ganglia region of the brain. It is an important part of the motor control system, and plays a crucial role in maintaining the proper balance between inhibitory and excitatory inputs to motor neurons. Research in neurological therapy has shown that the Globus Pallidus can be a target for therapeutic interventions in conditions such as Parkinson's disease. In this condition, there is an imbalance in the output of the Globus Pallidus, leading to increased inhibition of motor neurons and resulting in movement disorders. Therapeutic strategies targeted at the Globus Pallidus include deep brain stimulation, which involves the implantation of electrodes that modulate the activity of the structure. Gene therapy is also being explored as a potential treatment modality for conditions where the Globus Pallidus is implicated. Understanding the role of the Globus Pallidus in motor control is critical to the development of new therapeutic interventions for conditions that affect motor function. Advances in neuroscience research continue to shed light on the complex interactions between the Globus Pallidus and other structures in the basal ganglia, paving the way for improved treatment options for a range of neurological conditions.


From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.