Glioblastomas are one of the most aggressive types of brain tumors that occur in the brain or spine. These tumors originate in the glial cells and grow rapidly, infiltrating and modifying the surrounding neuronal tissue. Glioblastomas account for approximately 50% of all primary brain tumors and affect about 3 out of every 100,000 people. While the exact cause of glioblastoma is not well understood, it is believed that genetic mutations may play a critical role in its development. Individuals with a family history of glioblastomas are at a higher risk of developing this type of tumor. Age, environmental factors, and previous radiation exposure are also believed to be contributing factors. Symptoms of glioblastoma include headaches, seizures, cognitive and personality changes, and weakness on one side of the body. The diagnosis is usually made through CT or MRI scans, followed by a biopsy to confirm the type of glioma. Treatment options for glioblastomas include surgery, chemotherapy, and radiation therapy. Surgical removal of the tumor is usually the preferred option, followed by radiation therapy to kill any remaining cancer cells. Chemotherapy is typically used in combination with radiation therapy to improve the overall outcomes of treatment. In recent years, research has focused on developing new treatments for glioblastoma, such as immunotherapy and targeted therapy. These novel treatments aim to harness the body's immune system to fight cancer cells and target specific genetic mutations to prevent tumor growth. In conclusion, glioblastomas are aggressive brain tumors that require prompt and specialized treatment. Early diagnosis and timely intervention are crucial for improving patient outcomes. By investing in cutting-edge research and clinical trials, we can better understand the underlying mechanisms of glioblastoma and develop new treatment strategies to combat this devastating disease.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.