Endocannabinoids are natural compounds or lipids that are produced by the body’s own endocannabinoid system. The endocannabinoid system is responsible for regulating many physiological processes including inflammation, pain, mood, stress, and appetite. Endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), are the body’s own version of cannabinoids, which are found in the Cannabis plant. However, unlike cannabinoids produced by the plant, endocannabinoids are produced by the body in small amounts and are rapidly broken down by enzymes. Research has shown that endocannabinoids play a crucial role in neurological therapy. Studies have found that disturbances in the endocannabinoid system are associated with various diseases including neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease, epilepsy, and multiple sclerosis. Neurological research on endocannabinoids is focused on developing therapies to modulate the endocannabinoid system. This has led to the development of drugs such as Sativex, a prescription drug that contains THC and CBD, two cannabinoids found in Cannabis. Sativex has been found to be effective in treating spasticity and pain in multiple sclerosis patients. Additionally, research on the endocannabinoid system has led to the discovery of new targets for neurological therapy. For example, the endocannabinoid system has been found to play a role in regulating the formation of new nerve cells in the hippocampus, a region of the brain that is important for learning and memory. Overall, endocannabinoids have emerged as an important area of research for neurological therapy, with the potential to lead to new treatments for many neurological disorders.

From: Neurobiology

Related Article For "Endocannabinoids"

About (1) results

Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.