Dopamine Transporters

Dopamine transporters are an important topic in neurological research and therapy. The dopamine transporter (DAT) is a protein found in the brain that is responsible for the reuptake of dopamine, a neurotransmitter that is involved in a wide range of brain functions, including motivation, reward, and pleasure. Disruptions in dopamine transporter function have been linked to a number of neurological disorders, including Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and addiction. Researchers have worked to develop therapies that target the dopamine transporter and other components of the dopamine system in order to treat these conditions. One promising approach to treating Parkinson's disease involves the use of drugs that inhibit the activity of the dopamine transporter. These drugs can increase the concentration of dopamine in the brain, which can help to alleviate the symptoms of the disease. Similarly, drugs that modulate the activity of the dopamine transporter are being developed for use in treating ADHD. In addition to pharmacological approaches, researchers are also exploring the use of noninvasive brain stimulation techniques to modulate dopamine transporter function. Transcranial magnetic stimulation (TMS) is a technique that uses magnetic fields to stimulate specific areas of the brain, and recent studies have shown that TMS can be used to modulate dopamine transporter function in patients with depression. Overall, understanding the function of the dopamine transporter and developing therapies that target it will continue to be an important area of research in the field of neurology.


From: Neurobiology

Related Article For "Dopamine Transporters"

About (2) results

Article:

Evaluating the Efficacy of Gene Silencing in Dopaminergic Neuronal Cells In-Vitro using Gold Nanorods (GNR) with Different Surface Properties Complexed to DARPP-32 siRNA.

Journal:

Advanced Pharmaceutical Science And Technology

Article:

Concomitant in Vivo Voltammetric and Electrophysiological Analysis Indicate that Nociceptin/Orphanin FQ Affects Dopamine and then Serotonin Activities in Brain Substancia Nigra.

Journal:

International Physiology Journal