Depression, in its clinical form major depressive disorder, is a mood disorder characterized by persistent low mood and loss of interest or pleasure, accompanied by changes in sleep, appetite, energy, concentration, and self-worth, and in severe cases by suicidal ideation. Its neurobiology implicates dysregulated mo…
Depression, in its clinical form major depressive disorder, is a mood disorder characterized by persistent low mood and loss of interest or pleasure, accompanied by changes in sleep, appetite, energy, concentration, and self-worth, and in severe cases by suicidal ideation. Its neurobiology implicates dysregulated monoaminergic neurotransmission involving serotonin, dopamine, and norepinephrine, alongside hypothalamic-pituitary-adrenal axis dysfunction, neuroinflammation, and altered neuroplasticity within prefrontal-limbic circuits. Depression arises from interacting genetic, neurobiological, psychological, and social factors, and frequently co-occurs with anxiety, chronic medical and neurological conditions, and cognitive impairment, with bidirectional relationships to dementia and to chronic disease. It is assessed using validated rating scales and managed through pharmacotherapy, psychological interventions, and neuromodulation. Research in this area examines depression across diverse populations and contexts, including teachers, perinatal women, people with disability, and patients with chronic kidney disease and dementia, as well as its relationship to social support, discrimination, executive dysfunction, environmental stressors such as noise, and comorbid anxiety, and the efficacy of behavioral and psychosocial interventions. The journal publishes peer-reviewed research on the mechanisms, measurement, comorbidity, and treatment of depression.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 48 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Depression, linking to each citing work.