Research Topic · Peer-Reviewed

Dentate Gyrus

The dentate gyrus is a trilaminar region of the hippocampal formation that serves as the principal entry gateway for cortical input arriving via the perforant path from the entorhinal cortex. Its densely packed granule cells project mossy fibers onto the CA3 pyramidal field, and the structure is distinguished by its…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 13× across the literature 🔖 ISSN 2470-5020 🗓 Reviewed June 2026

Overview

The dentate gyrus is a trilaminar region of the hippocampal formation that serves as the principal entry gateway for cortical input arriving via the perforant path from the entorhinal cortex. Its densely packed granule cells project mossy fibers onto the CA3 pyramidal field, and the structure is distinguished by its sparse, pattern-separating coding and by ongoing adult neurogenesis within the subgranular zone. These properties make the dentate gyrus central to the encoding of distinct episodic memories, spatial discrimination, and the disambiguation of overlapping experiences. Granule-cell excitability is shaped by both somatic membrane properties and synaptic plasticity, including long-term potentiation at perforant-path inputs, and these processes are modulated by afferent activity, neuromodulators, and inflammatory or oxidative stress within the surrounding hippocampus. Research featured here examines how nociceptive and pain-related signaling alters synaptic and somatic plasticity in the rodent dentate gyrus, and how oxidative stress and pro-inflammatory mediators such as tumor necrosis factor alpha perturb hippocampal granule and pyramidal cells. Because dentate function underlies memory formation and is vulnerable to degeneration, the region is closely studied in relation to aging, neuroinflammation, mood disorders, and epileptogenesis, where altered granule-cell remodeling and circuit excitability are recurring themes.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 13 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Dentate Gyrus, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Neurological Research and Therapy (ISSN 2470-5020).

Journal editorial board
Ian J Martins · Australia Giuseppe Lanza · Italy Ion Codreanu · United States

This page summarises published research for orientation; it is not medical or professional advice.