Axotomy refers to the surgical or accidental cutting of nerve fibers or axons, leading to their permanent disruption. In neurological research and therapy, axotomy is a critical model for studying neuronal regeneration and repair mechanisms. It has been used to investigate the response of neurons to injury, including the effects of drugs and experimental therapies. Axotomy research has greatly expanded our understanding of the complex processes involved in nerve regeneration and repair. The cellular and molecular mechanisms that underlie these processes are still not fully understood, but studies on axotomy have yielded a wealth of information on how neurons respond to injury at various stages of development. One area where axotomy research has been particularly fruitful is in the treatment of neurological disorders such as spinal cord injuries, Alzheimer's disease, and peripheral nerve damage. Researchers are developing strategies to promote axon regeneration, enhance neuronal growth, and prevent the degeneration of neurons after injury. Experimental treatments, such as stem cell therapy and gene therapy, have shown promise in improving axon regeneration and reducing the impact of neurological diseases. Additionally, neuroprotective agents that prevent axon damage following injury are also being developed. In summary, axotomy is a valuable tool in neurological research and therapy. As we continue to make progress in understanding the regenerative capacity of nerve fibers, we may be able to develop more effective treatments for a range of neurological disorders.

From: Neurobiology

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Editor-in-chief: Zheng Jiang, Department of Neuroscience, The Johns Hopkins University School of Medicine.
Publication Type: Open Access Journal
Description: The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body. When something goes wrong with a part of your nervous system, you can have trouble moving, speaking, swallowing, breathing, or learning. You can also have problems with your memory, senses, or mood.