Dysregulation

of Toll-like Receptors Toll-like receptors (TLR) are proteins that are responsible for detecting the presence of pathogens and other danger signals. Dysregulation of TLRs can result in an overactive immune system, resulting in autoimmune disorders such as lupus, Crohn's disease, and multiple sclerosis. TLR dysregulation can also result in an impaired immune system, which can cause increased susceptibility to infections, increased susceptibility to allergies, and increased severity of infectious diseases. Dysregulation of TLRs can also contribute to chronic inflammatory conditions, including asthma and cardiovascular disease. As such, understanding the mechanisms of TLR dysregulation is important for the treatment and prevention of a range of diseases and disorders.