Journal of Otolaryngology Advances
ISSN: 2379-8572
Current Issue
Volume No: 2 Issue No: 1
share this page

Case Report | Open Access
  • Available online freely | Peer Reviewed
  • | Provisional

    Hearing Loss Induced for Pesticides in a Rural Worker: A Case Report

    Tereza Raquel R. Sena 1       Angelo Roberto Antoniolli 1    

    1Federal University of Sergipe


    The use of pesticides by agricultural workers without protection can damage the hearing. This report describes the characteristics of work with pesticides, and compares the results of high-frequency audiometry over 36 months.

    Received 21 Mar 2017; Accepted 19 Apr 2017; Published 05 Jun 2017;

    Academic Editor:Mohammad El-Anwar, Otorhinolaryngology department, Faculty of Medicine, Zgazig University, Zagazig

    Checked for plagiarism: Yes

    Review by: Single-blind

    Copyright©   2017 Tereza Raquel R. Sena ,et al

    Creative Commons License    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Competing interests

    The authors have declared that no competing interests exist.


    Tereza Raquel R. Sena, Angelo Roberto Antoniolli (2017) Hearing Loss Induced for Pesticides in a Rural Worker: A Case Report. Journal of Otolaryngology Advances - 2(1):12-16.
    Download as RIS, BibTeX, Text (Include abstract )


    The World Health Organization reported that 23% of global deaths are due to modifiable environmental factors in that use of pesticides are included1. Work in agriculture poses risks to rural workers when they are routinely exposed to pesticides.

    The occupational hearing loss has been mostly only attributed to noise although there are other agents that might contribute to its potentiation, among them pesticides2, 10. Studies have linked exposure to otoagressives agents, noise and ototoxics, at higher frequencies above 8kHz, before the others11, 12, 13.

    Studies reported harmful effects of pesticides to peripheral and central auditory pathways and in which the organophosphates can also be responsible for neurotoxicity to the auditory system2, 3, 4, 5, 6, 7, 8, 9, 10.

    In this report, will be presented a rural worker case exposed to pesticides. High-frequency audiometry was measured and the results were compared over a period of 36 months.

    Case History

    A 25-year-old family worker male reported regular and concurrent exposure to insecticides organophosphates, herbicide glyphosate, spraying weekly during four years. No individual protection equipament was identified.

    There was no report of previous otologic or metabolic disease, use of ototoxic medication, surgery or head trauma, social exposure to intense noise, use of alcohol, tobacco or drugs regularly. All ear canal inspection, distortion product otoacoustic emissions (DPOAE), pure tone audiometry at 0.5K, 1K, 2K, 3K, 4K, 6K and 8KHz, were normal. All tympanometry tests were Jerger’s Type “A” and acoustics reflex threshold were presents during 36 months.

    Pure-tone air audiometry was done with the frequencies of 0,5K, 1K, 2K, 3K, 4K, 6K and 8KHz and high-frequency audiometry at 9K, 10K, 11K, 12.5K, 14K, 16K, 18K and 20KHz, in ambient acording requirements of ISO 8253-1.

    The high-frequency audiometry was performed at four different moments: baseline, after 12, 24 and after 36 months. The results of initial tests and in the first year was normal, ie, conventional audiometry was close to normal and high-frequency audiometry revealed similar configuration.

    In the course of months, the rural worker showed no health change worthy of note or otologic complications. He was subjected to the same tests during the period. The results were normal in both ears, except in high-frequency audiometry in which it was observed worsening in thresholds 11K, 12.5K, 14K, 16K, 18K and 20KHz in the 24th and 36th mounths (Figure 1).

    Figure 1. Hearing tests over the months with worse results on high
    Figure 1.


    The World Health Organization linked more than 8 million of non-communicable diseases in world to the environment in which is included the agricultural work with pesticides1. These products lead to unintentional poisonings at home and in the workplace, they are estimated to cause thousand deaths annually with the major part being from preventable chemical exposures14.

    The pesticides in agriculture can volatilize and suspend into the air when sprayed and are hazardous to human health and to the enviroment. In Brazil, for each dollar spent on pesticides, approximately US$ 1.28 may be spent on health care and sick leave due to occupational poisoning15 and the number of cases was increasing in the Northeast16.

    Neurological diseases, cancer and others health problems have been associated with exposure to pesticides. Pesticides are neurotoxic agents that may cause hearing loss. The European Union recommends since 2003 that prevention programs also operate in the monitoring of workers exposed to chemical agents, but the work activities in rural areas usually occur as family production on small farms with no access for occupational safety standards17.

    Individual susceptibility to pesticides cannot be measured, but due to the use of pesticides weekly we believe there may be relationship to hearing loss presented.

    The hearing damages caused by ototoxicity are recognized and the use of high-frequency audiometry endorse the importance of this tool in the evaluation and monitoring of hearing loss13, 18, 19, 20.

    The invariable result in DPOAE in the case surveyed is in line with authors who found no significant difference between DPOAE and biomarkers in students exposed to pesticides7. It is believed that, similarly to the conventional audiometry, the frequency for DPOAE range did not suffer damage from ototoxic agents, in few years, as noted.

    In addition, over the years in this case report all tympanometry tests, acoustics reflex threshold and DPOAE were normal, but HFA was not. Aging has not interfered in the findings because the worker was younger and had no history of exposure to noisy environments, ototoxic drugs or metabolic diseases that could be cause hearing loss at high frequencies found.

    In the case investigated, we observed that only high-frequency audiometry had change, which reinforces the theory that pesticides may have ototoxic effects. The effect of toxic agents may cause hearing loss17and pesticides could be considered as ototoxic agents from the results shown.

    In middle or low-income countries, there are no specialized health procedures in rural areas, thus the population access to audiological tests is difficult1. In this context, the inclusion of the HFA on occupational exams could be of great value to the workers exposed to pesticides.

    High-frequency audiometry was an important audiological test for early identification of auditory alterations and in the auditory follow-up of subjects exposed to chemicals and also pesticides.


    The exposure to pesticides of different toxicities from the rural worker investigated was the only one harmful event to auditory system that may be associated with hearing loss found in the high frequencies.

    It is noteworthy that the lack of obligation, prescribed by law, for the hearing monitoring of workers exposed to chemical agents, requires a critical positioning of researchers, health professionals and work-safety organs to contribute positively to change this scenario.

    Removing pesticides from agricultural practice and reducing access to them would prevent many deseases and also ototoxic hearing loss. Agroecological practices in agriculture can be sustainable alternatives to minimize the use of pesticides, and actions of health and safety at work should be encouraged by the rulers.


    1. (2016) World Health Organization. Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks / Annette Prüss-Üstün … [et al]. Geneva: World Health Organization.
    2.MMM Bazílio, Frota S, Chrisman J R, Meyer A, CIF Asmus et al.Temporal auditory processing in rural workers exposed to pesticide. , Soc. Bras. Fonoaudiol.2012; 24(2), 174-80.
    3.Bielefeld E C, Hu B H, Harris K C, Henderson D. (2005) Damage and threshold shift resulting from coclear exposure to paraquat-generated superoxide. , Hearing 207(1), 35-42.
    4.Foltz L, Soares C D, MAK Reichembach. (2010) Perfil audiológico de pilotos agrícolas. , Arq. int. otorrinolaringol.(Impr.) 14(3).
    5.Gatto M P, Fioretti M, Fabrizi G, Gherardi M, Strafella E et al. (2014) Effects of potential neurotoxic pesticides on hearing loss: A review. , NeuroToxicology 42, 24-32.
    6.Guida H L, Morini R G, ACV Cardoso. (2010) Audiological evaluation in workers exposed to noise and pesticide. , Braz J Otorhinolaryngol 76(4), 423-427.
    7.Johnson A C, Morata T C. (2010) 142,Occupational exposure to chemicals and hearing impairment. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. NR2010 44-4.
    8.Kunst L R, Garcia M V, Machado A K, Barbisan F, Silveira A F. (2014) Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region. CoDAS. 26(3), 219-25.
    9.TRR Sena, Vargas M M, CCC Oliveira. (2013) Hearing care and quality of life among workers exposed to pesticides. Cien. Saude Colet. 18(6), 1753-61.
    10.Morata T C, Little B. (2002) Suggested guidelines for studying the combined effect of occupational exposure to noise and chemicals on hearing. Noise & Health 4(14), 73-87.
    11.Fabijańska A, Smurzyński J, Hatzopoulos S, Kochanek K, Bartnik G et al. (2012) The relationship between distortion product otoacoustic emissions and extended high-frequency audiometry in tinnitus patients. Part 1: normally hearing patients with unilateral tinnitus. Med Sci Monit. 18(12), 765-70.
    12.Lopes A C, Melo A D, Santos C C. (2012) A study of the high-frequency hearing thresholds of dentistry professionals. Int Arch Otorhinolaryngol. 16(2), 226-31.
    13.Mehrparvar A H, Mirmohammadi S J, Davari M H, Mostaghaci M, Mollasadeghi A et al. (2014) Conventional Audiometry, Extended High-frequency Audiometry, and DPOAE for Early Diagnosis of NIHL. Iran Red Crescent Med. 16(1), 9628.
    14. (2009) World Health Organization. Global health risks: mortality and burden of diseases attributable to selected major risks. Geneva: World Health Organization.
    15. (2016) World Health Organization. The public health impact of chemicals: knowns and unknowns. International Programme on Chemical Safety. Geneva: World Health Organization .
    16.Flávia Nogueira Ferreira-de-Sousa, Vilma Sousa Santana.Mortality from work-related accidents among agricultural workers in Brazil, 2000-2010." Cadernos de Saúde Pública 32,4.
    17.European Agency for Safety and Health at Work.Combined exposure to noiseand ototoxic substances.Luxembourg: Office for Official Publications of the European Communities.
    18.Gonçalves C G, Santos L, Lobato D, Ribas A, Lacerda A B et al. (2015) Characterization of hearing thresholds from 500 to 16,000 in dentists: a comparative study. Int Arch Otorhinolaryngol. 19(2), 156-60.
    19.Lüders D, Gonçalves C G, Lacerda A B, Ribas Â, Jd Conto. (2014) Music students: conventional hearing thresholds and at high frequencies. , Braz J Otorhinolaryngol; 80(4), 296-304.
    20.Maccà I, Scapellato M L, Carrieri M, Maso S, Trevisan A et al. (2015) High-frequency hearing thresholds: effects of age, occupational ultrasound and noise exposure. Int Arch Occup Environ Health. 88(2), 197-211.