Journal of Dentistry and Oral Implants
ISSN: 2473-1005
Current Issue
Volume No: 2 Issue No: 1
share this page

Editorial | Open Access
  • Available online freely | Peer Reviewed
  • Ozone Therapy in the Treatment of Periodontal Disease

    Alparslan Dilsiz 1      

    1Professor, Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum/ TURKEY.

    Received 18 Apr 2018; Accepted 28 May 2018; Published 29 May 2018;

    Copyright©  2018  Alparslan Dilsiz et al.

    License
    Creative Commons License    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Competing interests

    The authors have declared that no competing interests exist.

    Citation:

    Alparslan Dilsiz (2018) Ozone Therapy in the Treatment of Periodontal Disease. Journal of Dentistry And Oral Implants - 2(1):15-17.
    Download as RIS, BibTeX, Text (Include abstract )
    DOI10.14302/issn.2473-1005.jdoi-18-2076

    Introduction:



     

    The main goal of the conventional periodontal therapy is to control infection and thereby curb disease progression. The mechanical removal of the oral biofilm and adjunctive use of antimicrobial agents have been the conventional methods for periodontal therapy. However, no consensus has been reached on whether conventional periodontal therapy can eliminate periodontal pathogens.1,2,3 It has been known that medical ozone therapy eliminated 260 different pathogens. Thus, applications of medical ozone may provide a potential benefit in the treatment of periodontal diseases by reducing and eradicating subgingival periodontopathogenic species in inaccessible sites.4,5,6,7,8,9,10,11

    Applications of medical ozone are a new treatment modality that has been developing rapidly within various medical specialties since the 1930s. In 1933, Dr. E.A. Fish, first used ozone on a regular basis in his dental practice, and published numerous papers on the subject.4,8 Ozone (O3) is a triatomic molecule, consisting of three oxygen atoms. It is an unstable gas and quickly gives up nascent oxygen molecule to form oxygen gas. It is naturally produced by the photo dissociation of molecular oxygen (O2) into activated oxygen atoms, which then react with further oxgen molecules.12,13,14 Medical ozone is made from pure medical oxygen. It is produced commercially in ozone generators, which involves sending an electrical discharge through a specially-built condenser containing oxygen. Due to the property of releasing nascent oxygen, it has been used in human medicine an antimicrobial agent against bakteria, viruses, fungi, and protozoa. This effect of ozone is a result of its action on cells by damaging its cytoplasmic membrane due to ozonolysis of dual bonds and also ozone-induced modification of intra cellular contents (oxidation of proteins loss of organelle function) because of secondary oxidants effects. This action is non-specific and selective to microbial cells; it does not damage human body cells because of their major antioxidative ability.14 In the addition, there are several known actions of ozone on human body, such as stimulating of micro-circulation, immunostimulating and analgesic, antihypoxic and detoxicating, bioenergetic and biosynthetic (activation of the metabolism of carbonhydrates,proteins, lipids) etc.12,13,14,15,16

    While ozone has been evaluated by many clinical studies, the recent studies have reported controversial results about the benefits of its for periodontal treatment. Some current studies showed that a number of the periodontal pathogens are susceptible to medical ozone, suggesting that it is advantageous for conventional periodontal therapy4,5,6,7,8,9,10,11, whereas others reported that adjunctive use of ozone showed no significant benefits.17,18,19,20

    The some systematic reviews conclude that the inclusion of the ozone as an adjunct to conventional periodontal treatment seems to be therapeutically useful.12,13,14,15,16 Therefore, ozone when used as an adjunct to conventional periodontal therapy kills more bacteria than when conventional periodontal therapy is used alone. Further studies are required to investigate efficacy and cost benefits of this treatment modality.

    References

    1.Oda S, Nitta H, Setoguchi T, Izumi Y.Ishikawa I (2004)Current concepts and advances in manual and power-driven instrumentation.Periodontol 2000,36:. 45-58.
    2.Rhemrev GE,Timmerman MF,Veldkamp I,Van Winkelhoff AJ,Van der Velden U. Immediate effect of instrumentation on the subgingival microflora in deep inflamed pockets under strict plaque control. JClin Periodontol2006,33:. 42-48.
    3.Schenk G, Flemmig T F, Lob S, Ruckdeschel G.Hickel R.Lack of antimicrobial effect on periodontopathic bacteria by ultrasonic and sonic scalers. in vitro.J Clin Periodontol 2000,27 : 116-119.
    4.Yilmaz S, Algan S, Gursoy H, Noyan U, Kuru B E. (2013) Evaluation of the clinical and antimicrobial effects of the Er:YAG laser or topical gaseous ozone as adjuncts to initial periodontal therapy. Photomed Laser Surg. 31, 293-298.
    5.Hauser-Gerspach I, Vadaszan J, Deronjic I, Gass C, Meyer J. (2012) Influence of gaseous ozone in peri-implantitis: bactericidal efficacy and cellular response. An in vitro study using titanium and zirconia. Clin Oral Investig. 16, 1049-1059.
    6.Eick S, Tigan M, Sculean A. (2012) Effect of ozone on periodontopathogenic species--an in vitro study. Clin Oral Investig. 16, 537-544.
    7.Huth K C, Quirling M, Lenzke S, Paschos E, Kamereck K.et al.(2011) Effectiveness of ozone against periodontal pathogenic microorganisms. , Eur J Oral Sci,119: 204-210.
    8.Huth K C, Jakob F M, Saugel B, Cappello C, Paschos E. (2006) Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci. 114-435.
    9.Sechi L A, Spanu T, Sanguinetti M, Dupre I, Masucci L. (2001) Molecular analysis of Klebsiella pneumoniae strains isolated in pediatric wards by ribotyping, pulsed field gel electrophoresis and antimicrobial susceptibilities. , New Microbiol 24, 35-45.
    10.Muller P, Guggenheim B, Schmidlin P R. (2007) Efficacy of gasiform ozone and photodynamic therapy on a multispecies oral biofilm in vitro. , Eur J Oral Sci,115: 77-80.
    11.Nagayoshi M, Fukuizumi T, Kitamura C, Yano J, Terashita M.Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol Immunol2004,19:. 240-246.
    12.Gupta G, Mansi B. (2012) Ozone therapy in periodontics. , J Medicine and Life,5; 59-67.
    13.Garg R, Tandon S. (2009) Ozone: A new face of dentistry. , The Internet Journal of Dental Science;7: 2.
    14.Seidler V, Linetskiy I, Hubalkova H, Staňkova H, Šmucler R.Ozone and Its Usage in General Medicine and Dentistry. A Review Article. Prague Medical Report2008,109:. 5-13.
    15.Saini R.Ozone therapy in dentistry: A strategic review. , J Nat Sc Biol Med2011;2: 151-153.
    16.Azarpazhooh A, Limeback H.The application of ozone in dentistry: a systematic review of literature.J. Dent.2008,36: 104-16.
    17.Skurska A, Pietruska M D, Paniczko-Drezek A, Dolinska E, Zelazowska-Rutkowska B. (2010) Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Adv Med Sci. 55, 297-307.
    18.Al Habashneh R, Alsalman W, Khader Y. (2015) Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial. J Periodontal Res. 50, 37-43.
    19.Hayakumo S, Arakawa S, Mano Y, Izumi Y. (2013) Clinical and microbiological effects of ozone nano-bubble water irrigation as an adjunct to mechanical subgingival debridement in periodontitis patients in a randomized controlled trial. Clin Oral Investig. 17, 379-388.
    20.Kshitish D, Laxman V K. (2010) The use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: a clinical and microbiologic study. Indian J Dent Res. 21, 341-348.