Journal of Clinical Case reports and Images

Journal of Clinical Images and Case reports

Journal of Clinical Images and Case Reports

Current Issue Volume No: 1 Issue No: 1

Case Report Open Access Available online freely Peer Reviewed Citation

Rapid Calcification of Myocardium as Sequela from Severe Sepsis

1University Hospital Wurzburg, Department of Diagnostic and interventional Radiology

Author Contributions
Received 30 Mar 2017; Accepted 26 Apr 2017; Published 08 Aug 2017;

Academic Editor: Anil TOMBAK, Mersin University Faculty of Medicine

Checked for plagiarism: Yes

Review by: Single-blind

Copyright ©  2017 Andreas S. Kunz, et al

Creative Commons License     This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing interests

The authors have declared that no competing interests exist.


Andreas S. Kunz, Matthias Beissert, Thorsten Klink (2017) Rapid Calcification of Myocardium as Sequela from Severe Sepsis. Journal of Clinical Images and Case reports - 1(1):1-2.

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DOI 10.14302/issn.2641-5518.jcci-17-1509

The Case

The reported case shall highlight severe sepsis as possible cause of myocardial calcification, as well as the highly dynamic development thereof within a time span of merely 10 weeks. A 60-year-old male patient had been admitted to hospital for palliative therapy of progressive multiple myeloma, which lately had transformed into plasma cell leukemia. After commencing his third therapy cycle with Elotuzumab, the patient suffered from a pneumogenic sepsis due to staphylococcus infection that required mechanical ventilation for 7 days. Antimicrobial therapy followed antimicrobial susceptibility testing and included Tazobactam, Piperacillin, and Fosfomycin. During his hospital stay, computed tomography images of the chest were acquired initially, i.e. at onset of pneumogenic sepsis (Figure 1.: left panel), as well as after 10 weeks (Figure 1: right panel) to follow-up pneumonia consolidations in both upper lung lobes. Surprisingly, non-contrast enhanced follow-up CT images revealed newly developed calcifications within the outer myocardial layers of the left ventricle.

Figure 1.Non-contrast enhanced CT scans of the chest initially during onset of pneumogenic sepsis (right) and after 10 weeks (left) show rapid development of non-preexisting, extensive myocardial calcifications.
 Non-contrast enhanced CT scans of the chest initially during onset of pneumogenic sepsis (right) and after 10 weeks (left) show rapid development of non-preexisting, extensive myocardial calcifications.

Only very few reports exist describing myocardial calcification as sequela from severe sepsis. Explanations attribute alterations of myocardial microcirculation to cause subsequent tissue necrosis during septic shock and capillary leak and relative capillary stasis.1 Resulting interstitial and intracellular edema, and consecutive mitochondrial destruction and cellular necrosis.2 In other cases, myocardial calcifications have been described as complication resulting from myocarditis.3

In general, myocardial calcifications are associated with myocyte necrosis due to severe infection or inflammation, and can lead to restrictive cardiomyopathy. Differential diagnoses include calcifications of the inner myocardial layers, which can be detected after myocardial infarction, and pericardial calcifications that indicate constrictive pericarditis.


  1. 1.Hinshaw L B. (1996) Sepsis/septic shock: participation of the microcirculation. , Crit Care Med 24, 1072-1078.
  1. 2.Hersh M. (1990) Histologic and ultrastructural changes in non-pulmonary organs during early hemodynamic sepsis. , Surgery 107, 397-410.
  1. 3.Wang K Y.(Mar2017,12) Calcifying giant cell cardiomyopathy: a possible new entity: Images in Cardiovascular Pathology. Cardiovasc Pathol. (Epub ahead of print);. 28, 68-70.

Cited by (3)

  1. 1.Cappelletti Simone, Piacentino Daria, Ciallella Costantino, 2020, A systematic review of radiological and histological findings of septic myocardial calcifications, Journal of Forensic and Legal Medicine, 74(), 102026, 10.1016/j.jflm.2020.102026
  1. 2.Ahmed Talha, Inayat Faisal, Haq Muhammad, Ahmed Taha, 2019, Myocardial calcification secondary to toxic shock syndrome: a comparative review of 17 cases, BMJ Case Reports, 12(1), bcr-2018-228054, 10.1136/bcr-2018-228054
  1. 3.Li Joy, Chelala Lydia, Hossain Rydhwana, Jeudy Jean, White Charles, 2021, Rapid Onset Development of Myocardial Calcifications in the Setting of Renal Failure and Sepsis, Radiology: Cardiothoracic Imaging, 3(2), e200549, 10.1148/ryct.2021200549