Journal of Advanced Pharmaceutical Science And Technology

Journal of Advanced Pharmaceutical Science And Technology

Journal of Advanced Pharmaceutical Science and Technology

Current Issue Volume No: 2 Issue No: 2

Research Article Open Access Available online freely Peer Reviewed Citation

Pharmacological Importance of Sage and Oregano 

Nida Tabassum Khan 1  

1Department of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of Information Technology Engineering and Management Sciences, (BUITEMS), Quetta, Pakistan 

Abstract

Sage and Oregano, both are well-known culinary herbs with potential medicinal uses. Sage is mostly used to cease wounds bleeding, treating sores, swelling, cough and ulcers back in the first century and was called as the fertility drug since it reduces excessive bleeding during menstruation. On the other hand Oregano was found to be effective in treating stomach discomforts, bacterial/fungal infection, inflammatory bowel disease etc. Therefore due to their therapeutic and native applications, Sage and Oregano is of high economic worth.

Author Contributions
Received 21 Apr 2020; Accepted 28 Apr 2020; Published 30 Apr 2020;

Academic Editor: Fatma mohammed Mady, Department of Pharmaceutics, Minia University, Egypt. 

Checked for plagiarism: Yes

Review by: Single-blind

Copyright ©  2020 Nida Tabassum Khan

License
Creative Commons License     This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Competing interests

No author has any associations that may represent a potential conflict of interest.

Citation:

Nida Tabassum Khan (2020) Pharmacological Importance of Sage and Oregano . Journal of Advanced Pharmaceutical Science And Technology - 2(2):13-17. https://doi.org/10.14302/issn.2328-0182.japst-20-3331

Download as RIS, BibTeX, Text (Include abstract )

DOI 10.14302/issn.2328-0182.japst-20-3331

Introduction

Sage is a herbaceous perennial herb belonging to the mint family that is enriched in essential antioxidants and is scientifically known as Salvia officinalis1. Besides being used in culinary due to its spicy aroma it is reported to possess antimicrobial potential against numerous gram positive/negative bacteria i.e. commonly food born pathogens 2, 3.

Bioactive Compounds in Sages Extract

Sage extract is reported to contain high percentage of volatile oils and other vital phenolic compounds which is responsible for its strong aroma and flavor 4.The following enlisted bioactive constituents are abundant in its extract: Low molecular weight sesquiterpenes and monoterpenes, oleanolic acid, triterpenoids, ursolic acid, α/ β thujone, rosmarenic acid, camphor, α/β-pinene, cineole, borneol, chlorogenic acid, phenyl propanoid, shikimate, mevalonate, carnosic acid, methyl rosmarenate, cinnamic acid, caffeic acid, salvianolic acids, quinic acid, quercetin, ferulic acid, luteolin , apigenin, etc 5, 6, 7, 8.

Health Benefits of Sage

The following are some therapeutic applications of Sage:

Anti-Inflammatory: Rosmarinic acid in Sage is responsible for its anti-inflammatory property and is used in the preparation of medicines to reduce mouth/throat inflammation such as gingivitis and pharyngitis 9.

Anti-Microbial: Sage herb extract is reported to possess antibacterial and antifungal activity against S.aureus, E. coli, Salmonella species etc 10 and C. albicans respectively 11.Additionally, Sage is also effective in treating infections of throat, dental problems such as bleeding gums, mouth ulcers etc and infantile diarrhea 12.

Relaxant: Research suggested that Sage herb is useful in curing nervous excitement and dizziness 13.Besides it has an anti-spasmodic action which reducesmuscle tension and aid in removing mucous congestion in the respiratory tracts 14, 15.

Stimulant: Sage extract stimulates digestion by enhancing intestinal/pancreatic secretions, and bile flow 16.

Moderates Menopause: Sage leaf extract is reported to reduce excessive sweating, symptoms of dysmenorrhea, amenorrhoea and breast-milk production 17.

Enhances Memory: Sage is documentedto improve neural function by inhibiting the acetylcholinesterase activity and is reported to be under investigation for the treatment of Alzheimer's disease 18.

Anti-Oxidant: Research suggested that sage extract is enriched incompounds namely carnosol, rosemarinic acid, methyl carnosate, caffeic acid and carnosic acid that contributes towards its radical-scavenging properties and also offers hepatic protection 19.

Anti-Diabetic: This herb is claimed to be anti-diabetic because it elevates hepatocyte sensitivity to insulin and inhibits gluconeogenesis thus producing hypoglycaemic effects in diabetic individuals 20.

Anti-Tumour: Sage possess anti-proliferative activity in cancer cell lines of human and is considered as an antitumor agent21.In addition it showed cytotoxic activity on human prostate carcinoma cells22.Thus it is used in treating cancers and tumours in humans.

Other Uses: Sage or its extract are employed in the preparation of toothpastes, hair shampoos and preservatives 23.

Oregano is scientifically known as Origanum vulgare and commonly called as marjoram, it is native to northern Europe and has been used for curing numerous ailments 24. It is a small perennial herb with multi-branched stems covered with small grayish-green oval leaves and small white or pink flowers 25.

Health Benefits of Oregano

The following are some therapeutic applications of Oregano:

Anti-Fungal: Oregano has been reported to be used in the treatment of chronic candidiasis by inhibiting the growth of C. albicans because it possess antifungal properties attributed to the presence of thymol and carvacol compounds 26.

Anti-Bacterial: Oregano is extremely effective against bacteria including E. coli, P. aeruginosa, S. enterica and S. aureus 27.In addition it also effective against amoeba G. lamblia 28.

Anti-Oxidant: Due to the presence of compounds like rosmarinic acid and thymol, oregano extracts has the potential to prevent cell damage that is caused by the generation of free radicals 29.

Source of Nutrition: Oregano is an enriched source of essential nutrients such as fiber, manganese, calcium, iron and vitamin K/A/C 30.

Promotes Digestion: Oregano promotes regular digestion, reduces heartburn, and lowers stomach acidity 31.

Anti-Inflammatory: Oregano extracts is used in the treatment of inflammatory bowel disease 32.

Side Effects of Sage and Oregano Excess Use

The following are some side effects observed in individuals using these above mentioned herbs in excess:

Allergic reactions in individuals who have allergies to herbs belonging to family Lamiaceae33.

Sage or Oregano extracts should not be taken in excess during pregnancy since both of these herbs increase the risk of bleeding and may lead to miscarriage 34

Stomach upset, intestinal tract discomfort, skin irritation and burning sensation are some common side effects reported when these herbs or its extracts are consumed in excess 35.

Conclusion

Thus both the herbs Oregano and Sage besides being used in culinary, possess numerous health benefits such as being anti-fungal,anti-bacterial, anti-inflammatory,relaxant,stimulant and anti-oxidant.

References

  1. 1.N B Perry, R E Anderson, N J Brennan, M H Douglas, A J Heaney et al. (1999) Essential oils from Dalmatian sage (Salvia officinalis L.): variations among individuals, plant parts, seasons, and sites. , Journal of agricultural and food chemistry 47(5), 2048-2054.
  1. 2.M E Cuvelier, Berset C, Richard H. (1994) Antioxidant constituents in sage (Salvia officinalis). , Journal of Agricultural and food chemistry 42(3), 665-669.
  1. 3.Delamare A P L, I T Moschen-Pistorello, Artico L, Atti-Serafini L, Echeverrigaray S. (2007) Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South Brazil. Food chemistry. 100(2), 603-608.
  1. 4.N E Durling, O J Catchpole, J B Grey, R F Webby, K A Mitchell et al. (2007) Extraction of phenolics and essential oil from dried sage (Salvia officinalis) using ethanol–water mixtures. Food chemistry. 101(4), 1417-1424.
  1. 5.Martins N, Barros L, Santos-Buelga C, Henriques M, Silva S et al. (2015) Evaluation of bioactive properties and phenolic compounds in different extracts prepared from Salvia officinalis L. Food chemistry. 170, 378-385.
  1. 6.A V Pop, Tofana M, S A, Varban D, Nagy M et al. (2015) Evaluation of antioxidant activity and phenolic content in different Salvia officinalis L. extracts. , Bull UASVM Food Sci Technol 72(2), 210-4.
  1. 7.Jasicka-Misiak I, Poliwoda A, Petecka M, Buslovych O, V A Shlyapnikov et al. (2018) . Antioxidant phenolic compounds in Salvia officinalis L. and Salvia sclarea L. Ecological Chemistry and Engineering S 25(1), 133-142.
  1. 8.M B Farhat, Landoulsi A, Chaouch-Hamada R, J A Sotomayor, M J Jordán. (2013) Characterization and quantification of phenolic compounds and antioxidant properties of Salvia species growing in different habitats. , Industrial Crops and Products 49, 904-914.
  1. 9.J B Park. (2011) Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme. International journal of food sciences and nutrition. 62(6), 577-584.
  1. 10.Mitić-Ćulafić D, B S Vuković-Gačić, J B Knežević-Vukčević, Stanković S, D M Simić. (2005) Comparative study on the antibacterial activity of volatiles from sage (Salvia officinalis L.). , Archives of Biological Sciences 57(3), 173-178.
  1. 11.Izcan M, Boyraz N. (2000) Antifungal properties of some herb decoctions. , European Food Research and Technology 212(1), 86-88.
  1. 12.Anushri M, Yashoda R, M P Puranik. (2015) Herbs: A good alternatives to current treatments for oral health problems. dermatitis (from topical application). 7, 9-12.
  1. 13.Abascal K, Yarnell E. (2004) Nervine herbs for treating anxiety. , Alternative & Complementary Therapies 10(6), 309-315.
  1. 14.Baricevic D, Sosa S, Della L R, Tubaro A, Simonovska B et al. (2001) Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. , Journal of Ethnopharmacology.75(2-3): 125-132.
  1. 15.Sultana S, Khan A, Safhi M M, Alhazmi H A. (2016) Cough suppressant herbal drugs: A review. , International Journal of Pharmaceutical Science Invention 5(5), 15-28.
  1. 16.FrAnKIČ T, Voljč M, Salobir J, Rezar V. (2009) Use of herbs and spices and their extracts in animal nutrition. , Acta Agric Slov 94(2), 95-102.
  1. 17.Israel D, E Q Youngkin. (1997) Herbal therapies for perimenopausal and menopausal complaints. , Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17(5), 970-984.
  1. 18.Ferreira A, Proença C, Serralheiro M L M, Araujo M E M. (2006) The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. , Journal of ethnopharmacology 108(1), 31-37.
  1. 19.Miliauskas G, P R Venskutonis, Beek T A Van. (2004) Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food chemistry. 85(2), 231-237.
  1. 20.Eidi A, Eidi M. (2009) Antidiabetic effects of sage (Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats. , Diabetes & Metabolic Syndrome: Clinical Research & Reviews 3(1), 40-44.
  1. 21.Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. (2013) Sage: The functional novel natural medicine for preventing and curing chronic illnesses. , International Journal of Case Reports and Images 4(12), 671-677.
  1. 22.W J Craig. (1999) Health-promoting properties of common herbs. The American journal of clinical nutrition. 70(3), 491-499.
  1. 23.Joshi L S, Pawar H A. (2015) Herbal cosmetics and cosmeceuticals: An overview. , Nat Prod Chem Res 3(2), 170.
  1. 24.Milos M, Mastelic J, Jerkovic I. (2000) Chemical composition and antioxidant effect of glycosidically bound volatile compounds from oregano. (Origanum vulgare L. ssp. hirtum). Food chemistry 71(1), 79-83.
  1. 25.Fleisher A, Sneer N. (1982) Oregano spices and Origanum chemotypes. , Journal of the Science of Food and Agriculture 33(5), 441-446.
  1. 26.J C Stiles, Sparks W, R A. (1995) The inhibition of Candida albicans by oregano. , Journal of Applied Nutrition 47, 96-102.
  1. 27.Ozkalp B, Sevgi F, Ozcan M, M. (2010) The antibacterial activity of essential oil of oregano (Origanum vulgare L.). , J Food Agric Environ 8(2), 272-4.
  1. 28.D L, W S Sparks, R A, D R. (1999) . U.S. Patent No. 5,955,086. Washington, DC: U.S. Patent and Trademark Office .
  1. 29.Bendini A, T G, Lercker G. (2002) Antioxidant activity of oregano (Origanum vulgare L.) leaves. Italian journal of food science. 14(1), 17-24.
  1. 30.Lagouri V, Boskou D. (1996) Nutrient antioxidants in oregano. International journal of food sciences and nutrition. 47(6), 493-497.
  1. 31.Bettermann E.15 Oregano Oil Uses & Benefits for Body and Mental Health.
  1. 32.Singletary K. (2010) Oregano: overview of the literature on health benefits. , Nutrition Today 45(3), 129-138.
  1. 33.Anibarro B, F J Seoane, M V. (2007) Involvement of hidden allergens in food allergic reactions. , Journal of Investigational Allergology and Clinical Immunology 17(3), 168.
  1. 34.S E Kintzios. (2012) . Oregano. In Handbook of herbs and spices. Woodhead Publishing 417-436.
  1. 35.Aggarwal B B, Yost D. (2011) Healing Spices: How to Use 50 Everyday and Exotic Spices to Boost Health and Beat Disease.SterlingPublishingCompany.