Structural Basis

of membrane protein-protein interactions Membrane proteins are proteins that are embedded in or associated with cellular membranes. They have critical roles in cellular physiology, including recognition of hormones and other molecules, cell adhesion, signal transduction, and transport of proteins and lipids. In order for these proteins to carry out their functions, they must interact with each other through protein-protein interactions (PPIs). Structural analysis of PPIs provides valuable insight into the mechanisms and dynamics of these interactions. Such studies can reveal how PPIs mediate protein assembly, how they contribute to cell signalling pathways, and how they contribute to the structural and functional integrity of the cell membrane. Understanding PPIs at the structural level is therefore essential for understanding the biological roles of membrane proteins and their importance in human health and disease.