Structural and Molecular Interrogation of Intact Biological Systems

Structural and molecular interrogation of intact biological systems enables direct observation and characterization of biological systems in native environments. This approach is used to study the structure and dynamic behavior of individual molecules and how they interact with and affect their surrounding environment. Molecular interrogation of intact biological systems is critical for understanding how biological systems function and for developing treatments for diseases. It is an essential tool for drug discovery and disease diagnosis, as well as for developing strategies for engineering and manipulating biological systems. Additionally, molecular interrogation of intact biological systems can be a powerful tool for advancing the fields of biotechnology and synthetic biology.

← International Journal of Structural Biology

Related Articles

66 article(s) found

The Balance 2∙f (O) – f (H) as a Cornerstone in Formulation of Electrolytic Systems

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Molecular Cytogenetic Investigations in a Novel Chromosomal Abnormality of t(10;15)(q22;q22) in a Pediatric Precursor-B-Acute Lymphoblastic Leukemia Patient

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A Review of the Histologic, Genetic and Molecular Characteristics of Meningioma Pathogenesis and Progression

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Understanding Ubl-Rpn1 Intermolecular Interaction

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Oxidative Telomere Attrition, Nutritional Antioxidants and Biological Aging

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Investigations of Molecular Evolutionary Mechanisms in Partially Sequenced Heat Shock Protein70 Homologue-Coding Gene of Olive Leaf Yellowing-Associated Virus Isolates from Tunisia

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Preliminary Survey on The Termite Mounds, Their Interior Geometrics and The Termite Prevention from Infrastructural Construction at New Site of Ndola International Airport in Zambia

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Functional, Structural and Contextual Analysis of a Variant of Uncertain Clinical Significance in BRCA1: c.5434C->G (p. Pro1812Ala)

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Supporting Quality Data Systems:  Lessons Learned from Early Implementation of Routine Viral Load Monitoring at a Large Clinic in Lilongwe, Malawi

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Molecular Structure and Vibrational Analysis of 2-(4-methoxyphenyl)-2, 3-Dihydro-1H-Perimidine using Density Functional Theory

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Molecular Spectroscopy and Molecular Docking Studies on (E)-1-(4-Bromobenzylidene) Thiourea

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General Evolution of the Universe Driven by Attraction and Four Levels of Biological Evolution as its Essential Part

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Electrospun Biopolyesters: Hydrophobic Scaffolds with Favorable Biological Response

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Quantitative Microbiological Risk Assessment: Underrated Tool in Process Improvement in Food Microbiology

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Molecular and Cell Biological Considerations in the Initiation and Development of Sporadic Non-Hereditary Solid Cancers  

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Microbiological and Nutritional Properties of Frankfurter-Type Fish Sausage

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The Biological Basis of Cellular Diabetes Mellitus

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Perioperative Period is a Critical Gap for Minimal Residual Cancer Cells Progression and Therapy: Biological and Molecular Based Evidences

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Biological Networks: An Introductory Review

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Molecular Biomarkers: A Brief Review

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The Comparison of Walking Performance in Cold and Warm Biologically Conditions in Physiology

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Women’s Empowerment and the Integration of Traditional Maternal and Child Healthcare with National Health Systems in the Republic of Guinea.

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Molecular Survey on Symbiodinium of Some Scleractinean Coral Spp. and a Fire Coral sp. along the Red Sea of Egypt

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Neurobiological Differences Between Aggression and Agitation in Persons with DementiaAffiliation

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Molecular Composition of and Potential Health Benefits Offered by Natural East African Virgin Sunflower Oil Products: A 400 MHz 1H NMR Analysis Study

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Developing Cellular & Molecular Biomarkers for Anti-Inflammatory Activities of Probiotic Bacteria in Fermented Foods

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Acute Pneumonia: Biological Rules and Laws require Attention and Respect.

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Construction of Virtual Neuron and Consolidation of Sleep and Memory Process– A Molecular Docking and Biomathematical Approach

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Mathematical Analysis of Alternative Power Systems in a Northern Wisconsin Home

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Molecular and Metabolic Pathogenesis of Familial Combined Hyperlipidemia and Association with Metabolic Syndrome

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Analysis and Forecast Based on the Kinetic Equation for Changing the Numerical Composition of Living Systems

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Structural Equation Modeling to Detect Predictors of CD4 Cell Count Change due to Long Term Antiretroviral Therapy Administered to HIV-Positive Adults at Felege Hiwot Teaching and Specialized Hospital, Bahir Dar, Ethiopia

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Formulation of Isohydricity Conditions in Acid-Base systems - A Review

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Molecular Study of Hepcidin HAMP (-582A/G) Gene Polymorphisms and Measurement of Serum Hepcidin Level among Sudanese Patients with Anemia of Chronic Kidney Disease

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Biomedical Infophysical Models of Filtering Ghost Airflows by Wearing Masks and Maintaining Social Distancing to Prevent COVID-19 and Reopen All Systems after Shutdowns (Lockdowns)

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Health Systems of Underdeveloped and Developing Countries

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Molecular Analysis of 6-pyruvoyltetrahydropterin Synthase Gene in Atypical Phenylketonuric Egyptian Patients

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Quantification and Comparison of Opium (Morphine) and Tramadol from Biological Samples "Liquid - Liquid Extraction"

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Evaluation of Biological Activities of Opuntia Ficus Indica Cladodes Extract Against Cadmium-Induced Osteoporosis in Male Wistar Rats

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Aerobic Plate Count of Contaminants and Molecular Characterization of Eschereichia Coli in Raw Chicken Meat in Ismailia, Egypt

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GATES/GEB as the Best Thermodynamic Approach to Electrolytic Redox Systems - a Review

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Assessment of Body Size by Structural Equation Model Using Anthropometric Traits of Fishermen Community: A Methodological Approach

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Biological Effects of High Radiofrequency Radiation on Wistar Rats: A Literature Review

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Molecular Evolutionary Characteristics of the 2019 Novel Coronavirus (SARS-CoV-2) Contracted by Tunisian Citizens : Comparison and Relationship to Other Human and Animal Coronaviruses Based on Spike Glycoprotein-Coding Gene Sequences Analysis

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Structural Characterization and Isotopic Abundance Ratio Analysis of the Consciousness Energy Healing Treated Ofloxacin

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Molecular Evolution of the Novel Coronavirus SARS-CoV-2

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Use of the Remaining Sample from the Panbio COVID-19 Antigen Rapid Test Device for the Molecular Screening of the SARS-CoV-2 Variant of Concern B.1.1.7

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The trajectory of immunoglobulins immune response against the different amounts of xenobiotics matches the trajectory of biological changes associated with ageing: A systematic review

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Evolution of the Solid Human Tumor Cells Properties in Various Experimental Systems in Vitro

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Six Fractal Codes of Biological Life Unifying ATOMS, WAVES and INFORMATION: Perspectives in Exobiology, Cancers Basic Research and Artificial Intelligence Biomimetism Decisions Making

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Tay-Sachs Disease: From Molecular Characterization to Ethical Quandaries and the Possibility of Genetic Medicine

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Molecular Detection of Mycoplasma Gallisepticum and Mycoplasma Synoviae Infection in Poultry

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Antibacterial Activities of Ni Substituted Ferrite Particles for Biological Applications

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Molecular Confirmation of Staphylococci Strain’s Identification Isolated in the Hospital and University Center of Brazzaville, Republic of Congo

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CERN Large Hadron Collider (LHC) Radiation Source for Magnetic Resonance Biospectroscopy in Metabolic and Molecular Imaging and Diagnosis of Cancer

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Comprehensive Study of Structural, Optical and EPR Properties of Mn2+ Doped CdSe Nanocrystals

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The Energy–Matter–Behavioral Model of Mental Health Hygiene: A Systems-Based Framework for Sustainable Well-Being

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Molecular Diagnosis in Clinical Management and Diagnosis of Thyroid Cancer

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The Heart Physiology in Fertile Female and The Heart Pathophysiology in Post Menopausal Female. The Contribution of Molecular Biology, Maintaining Cardiac Hemodinamy and Electrophysiology

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Exercises Pursued by Older Adults with Osteoarthritis and Their Structural Impacts are Hard to Uncover; a Scoping Review of Selected 1970-2024 Studies

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RBM45: Molecular, Cellular, and Evolutionary Biology

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Why Do Human Body Systems Go Into Catastrophic System Failure Leading to Diseases -Is the Answer in Science or Nature?

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Bridging Gaps in Blood Transfusion Services through Collaborative Healthcare Systems in Cameroon: The Cornerstone University Blood Management System version 1.0

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Molecular Control of Human Embryonic Development: A Comprehensive Study

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Extended Bioethics as a Response to Global Biological Consciousness

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Molecular Approaches for Assessing Some Iranian Freshwater Fish Species

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