Research Topic · Peer-Reviewed

Immunotherapy

Immunotherapy is a treatment strategy that mobilises or modifies the immune system to recognise and eliminate disease, most prominently malignancy. Rather than acting directly on a tumour, it restores or amplifies host immune effector activity, particularly the cytotoxic T-cell response, against transformed or infec…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 42× across the literature

Overview

Immunotherapy is a treatment strategy that mobilises or modifies the immune system to recognise and eliminate disease, most prominently malignancy. Rather than acting directly on a tumour, it restores or amplifies host immune effector activity, particularly the cytotoxic T-cell response, against transformed or infected cells. The articles gathered here trace its principal mechanistic branches. Checkpoint blockade, exemplified by inhibition of the programmed cell death protein-1 pathway, releases the brakes that tumours exploit to evade T cells and has reshaped melanoma management. Adoptive cell transfer, including chimeric antigen receptor (CAR) T-cell engineering and its convergence with nanotechnology, equips patient-derived lymphocytes with redirected specificity. Combination approaches pair immunotherapy with radiation to convert irradiated tumours into in-situ vaccines, while immunomonitoring through immunoassays and immunogenomic profiling tracks response and resistance across cancer and infectious disease. Related work on oncofoetal antigens such as alpha-fetoprotein illustrates the antigen targets these therapies depend on. Collectively the collection situates immunotherapy as a distinct modality alongside surgery, chemotherapy and radiotherapy, with the capacity for durable remission balanced against immune-related toxicity, variable response rates, and the ongoing challenge of predicting which patients will benefit.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 11 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Immunotherapy, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Steroids.

Journal editorial board
Haewon Byeon · South Korea Reza Taherkhani · Iran Rosario Barone · Italy

This page summarises published research for orientation; it is not medical or professional advice.