Research Topic · Peer-Reviewed

Sepsis

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. In contemporary terms it is defined by infection accompanied by acute organ dysfunction, with septic shock denoting a subset marked by profound circulatory and cellular-metabolic derangement, persistent hypotension requ…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 13× across the literature

Overview

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. In contemporary terms it is defined by infection accompanied by acute organ dysfunction, with septic shock denoting a subset marked by profound circulatory and cellular-metabolic derangement, persistent hypotension requiring vasopressors, and elevated lactate. The underlying pathophysiology involves uncontrolled activation of inflammatory and coagulation pathways, endothelial injury, microvascular dysfunction, and impaired tissue oxygen utilization, which can progress to failure of the cardiovascular, respiratory, renal, and other systems and to manifestations such as lactic acidosis and acute respiratory distress. Early recognition through clinical and laboratory assessment, prompt source control, timely antimicrobial therapy, hemodynamic resuscitation, and organ support are decisive for survival, and risk-stratification tools and biomarkers assist prognostication and management. Sepsis remains a leading cause of in-hospital mortality across age groups, including neonates and surgical and critically ill patients, and recovery may require rehabilitation. The research reflected here includes rehabilitation of sepsis patients in intensive care, cardiac sequelae of severe sepsis, antimicrobial use in neonatal units, experimental systemic inflammatory response models, mortality risk scoring, and acidosis and respiratory complications. The journal publishes peer-reviewed studies on the pathophysiology, biomarkers, and clinical management of sepsis and critical illness.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 13 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Sepsis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Personalized Medicine.

Journal editorial board
Tarek Magdy Mohamed · United States Naranmandura Hua · China Bridget Bax · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.