Coronaviruses and immune response refers to the interaction between coronaviruses and the host immune system, encompassing how the body recognizes and defends against these RNA viruses and how viral infection in turn shapes immune activity. For SARS-CoV-2, the agent of COVID-19, the immune response is central to bot…
Coronaviruses and immune response refers to the interaction between coronaviruses and the host immune system, encompassing how the body recognizes and defends against these RNA viruses and how viral infection in turn shapes immune activity. For SARS-CoV-2, the agent of COVID-19, the immune response is central to both protection and pathology, because excessive or dysregulated inflammation can contribute to severe disease. Innate and adaptive mechanisms are engaged, including interferon signaling, cytokine production, and antibody-mediated immunity. Research examines how the viral spike protein influences interferon induction and the balance of cytokine gene expression, illuminating how the virus modulates host defenses. Antibody-based strategies are also studied, including the use of neutralizing antibodies delivered through convalescent immune plasma to prevent or limit infection. Nutritional and immunomodulatory approaches feature as well, such as dietary mannose-binding lectins proposed to reduce infection risk and immune modulators intended to strengthen antiviral responses. Molecular characterization of SARS-CoV-2, including evolutionary analysis of spike sequences, links viral variation to immune recognition and the durability of protection. Understanding coronaviruses and immune response integrates virology and immunology to clarify how protective immunity develops, how immunopathology arises, and how vaccines, antibodies, and immunomodulators can be designed to favor effective defense while limiting harmful inflammation.
9 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 9 articles above have been cited 28 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Coronaviruses and Immune Response, linking to each citing work.