Ubiquitin-proteasome System
The ubiquitin-proteasome system is a highly regulated process in which ubiquitin (a small protein tag) is attached to a substrate protein to mark it for degradation by the 26S proteasome. This type of protein degradation is a vital part of many cellular processes, such as cell cycle progression, signal transduction, and the regulation of protein abundance. Dysregulation of the ubiquitin-proteasome system has been implicated in many diseases, such as cancer, neurodegenerative diseases, and autoimmune diseases. Understanding how this system works can provide novel therapeutic strategies to treat these diseases.
← International Journal of Cell