Apoptotic Signaling Cascade

Apoptotic signaling cascade is a programmed cell-death process fundamental to the regulation of tissue homeostasis. It is a coordinated chain of molecular events that activate a specific set of genes resulting in cell death. This process is essential for the removal of aged and damaged cells during development, to maintain healthy tissue, and to eliminate potentially dangerous cells. The apoptotic signaling cascade is regulated by a variety of factors, including cell stress, growth factors, tumor suppressors, cytokines, and apoptotic activators. Dysregulation of the apoptotic signaling cascade has been linked to a variety of diseases, including cancer, cardiovascular disease, Alzheimer's disease, and diabetes. Apoptotic signaling cascade has become a major research focus in recent years due to its importance in regulating normal cell function and pathology.