Antibodies

Overview

Antibodies, also called immunoglobulins, are glycoproteins generated by B lymphocytes and plasma cells that bind antigens with high specificity, enabling the immune system to recognize and eliminate bacteria, viruses, and other threats. The basic molecule consists of paired heavy and light chains forming two antigen-binding arms, whose variable complementarity-determining regions dictate specificity, and a constant region that recruits effector mechanisms such as complement activation, phagocyte engagement, and signaling through Fc receptors. The isotypes IgG, IgM, IgA, IgE, and IgD differ in their structural and functional properties. Antibodies neutralize pathogens and toxins—exemplified by neutralizing antibodies in convalescent immune plasma against SARS-CoV-2—and constitute the protective output of vaccination. Engineered derivatives, including monoclonal antibodies, single-chain variable fragments, and single-domain antibodies, serve as therapeutics and diagnostic reagents, while autoantibodies are implicated in autoimmune and hematologic conditions. Antibody-based immunoassays such as ELISA are mainstays of diagnosis and of immunomonitoring in cancer and infectious disease. The research reflected here includes neutralizing antibodies in immune plasma, single-domain and monoclonal antibody generation, donor-specific anti-HLA antibodies in transplantation, autoantibodies in hematological malignancy, and immunoassay and immunogenomic approaches. The journal publishes peer-reviewed studies on antibody structure and function, antibody engineering, and immunodiagnostic applications.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia
  Dina Ashraf Abdelhady et al. · 2025 · European Journal of Medical Research
• Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia
  2025 · European journal of medical research
• Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
  2023 · Frontiers in Immunology
• Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
  R. Bailén et al. · 2023 · Frontiers in Immunology
• Dopamine D2 and Serotonin 5-HT1A Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain
  2022 · Biomolecules
• CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
  2022 · JCI Insight
• Dopamine D2 and Serotonin 5-HT1A Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain
  Agata Kowalik et al. · 2022 · Biomolecules
• CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
  2022 · JCI Insight

A sample of recent works citing this journal's research on Antibodies, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

Related topics