Research Topic · Peer-Reviewed

Plasma Cells

Plasma cells are terminally differentiated B lymphocytes whose specialized function is the high-rate secretion of antibodies. They arise when antigen-activated B cells, typically with T-cell help in germinal centers, undergo clonal expansion, class-switch recombination, and somatic hypermutation, then differentiate …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 15× across the literature 🗓 Reviewed June 2026

Overview

Plasma cells are terminally differentiated B lymphocytes whose specialized function is the high-rate secretion of antibodies. They arise when antigen-activated B cells, typically with T-cell help in germinal centers, undergo clonal expansion, class-switch recombination, and somatic hypermutation, then differentiate into antibody-secreting effector cells. Morphologically they display an eccentric nucleus and an extensive endoplasmic reticulum supporting immunoglobulin production, and long-lived populations home to the bone marrow to sustain durable humoral immunity. Each plasma cell produces antibody of a single specificity, and the collective output furnishes the body's defense against bacteria, viruses, and other pathogens, including neutralizing antibodies relevant to convalescent immune plasma. Dysregulated or neoplastic plasma cell proliferation underlies a spectrum of disorders, including monoclonal gammopathy of undetermined significance, plasmacytoma, and multiple myeloma, in which monoclonal immunoglobulin is overproduced; plasma cells also feature in inflammatory infiltrates of granulomatous and neoplastic tissue. Their study spans normal humoral immunity, hematologic malignancy, and the pathology of inflammatory lesions. The research reflected here includes extraosseous plasmacytoma, complications of multiple myeloma, monoclonal gammopathy, and plasma cell involvement in inflammatory infiltrates. The journal publishes peer-reviewed studies on plasma cell biology, related hematologic and oncologic disorders, and humoral immune responses.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Plasma Cells, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Anesthesia.

Journal editorial board
John Bebawy · United States Pradipta Bhakta · Ireland Mainul Haque · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.