Aminoacyl-trna Synthetases

Aminoacyl-tRNA synthetases (aaRSs) are a family of enzymes that are essential for all living organisms. They catalyze the attachment of amino acids to their cognate tRNAs and thus play a key role in translating genetic information from DNA into proteins. The 20 different aaRSs are further divided into two classes, class I and class II, based on the type of active site functionalities. Class I aaRSs comprise multiple active sites for amino acid loading, and class II is a monomeric enzyme composed of a single active site. Mutations in aaRSs are involved in various diseases including muscular dystrophy, cystic fibrosis, and cancer. In addition, aaRSs have potential for therapeutic applications in gene therapy, drug delivery, and diagnosis of diseases.

From: International Journal of Amino Acids

Related Article For "Aminoacyl-trna Synthetases"

About (1) results

Editor: Julia Piccoli, University of Sao Paulo-UNESP
Publication Type: Open Access Journal
Description: International Journal of Amino Acids encourages author to submit manuscripts to the journal for evaluation, from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation of amino acids.