Adp-ribosylation is a post-translational modification of proteins where the enzyme ADP-ribosyl transferase utilizes a molecule of NAD+ to place an adenosine diphosphate ribose group on a protein. This process is relevant to many vital cellular processes, including DNA repair, chromatin remodeling, organelle biogenesis and metabolism regulation. Adp-ribosylation is also an important mechanism for viral pathogens to subvert the host. By influencing the structure and/or activity of host proteins, ADP-ribosylation can regulate a variety of physiological processes, from differentiation to metabolism. As such, it is an important research target for elucidating the mechanisms of various diseases and identifying potential therapeutic targets.

From: International Journal of Amino Acids

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Editor: Julia Piccoli, University of Sao Paulo-UNESP
Publication Type: Open Access Journal
Description: International Journal of Amino Acids encourages author to submit manuscripts to the journal for evaluation, from all fields of amino acid and protein research: analysis, separation, synthesis, biosynthesis, cross linking amino acids, racemization/enantiomers, modification of amino acids as phosphorylation, methylation, acetylation of amino acids.