Research Topic · Peer-Reviewed

Cardiovascular Disorders Congenital Heart Disease

Congenital heart disease comprises structural abnormalities of the heart and great vessels that are present at birth, arising from disrupted cardiac morphogenesis during embryonic development. It is the most common category of major birth defect and ranges from simple lesions to complex malformations. Common defects…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 36× across the literature 🔖 ISSN 2329-9487 🗓 Reviewed June 2026

Overview

Congenital heart disease comprises structural abnormalities of the heart and great vessels that are present at birth, arising from disrupted cardiac morphogenesis during embryonic development. It is the most common category of major birth defect and ranges from simple lesions to complex malformations. Common defects include septal openings such as atrial and ventricular septal defects, obstructive lesions affecting valves and outflow tracts, and cyanotic conditions in which deoxygenated blood reaches the systemic circulation. Specific entities include Ebstein anomaly, a malformation of the tricuspid valve, and tetralogy of Fallot, while valvular abnormalities and coronary arterial variation further broaden the spectrum. The pathophysiology is driven by abnormal shunting of blood between systemic and pulmonary circulations, pressure or volume overload of cardiac chambers, and impaired oxygenation, which over time can produce pulmonary hypertension, ventricular dysfunction, arrhythmia, and heart failure. Etiology is multifactorial, involving chromosomal and single-gene disorders together with maternal and environmental exposures during gestation. Diagnosis relies on clinical examination, echocardiography, and advanced imaging, supported by neonatal screening to detect critical lesions early. Management spans surveillance, catheter-based intervention, and corrective or palliative surgery, with growing emphasis on lifelong follow-up because improved survival has produced a large population of adults with congenital heart disease who carry ongoing cardiovascular risk, including effects on exercise capacity.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 36 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cardiovascular Disorders Congenital Heart Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hypertension and Cardiology (ISSN 2329-9487).

Journal editorial board
Hatori Nobuo · Japan Gregor Leibundgut · Switzerland Yuejin Li · United States

This page summarises published research for orientation; it is not medical or professional advice.