Research Topic · Peer-Reviewed

Cardiac Hypertrophy

Cardiac hypertrophy is an abnormal thickening and enlargement of the heart muscle, particularly the walls of the chambers that pump blood, in response to increased workload or stress on the heart. It develops when the heart must work harder over time, most commonly as a result of chronic high blood pressure, which f…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 18× across the literature 🔖 ISSN 2329-9487 🗓 Reviewed June 2026

Overview

Cardiac hypertrophy is an abnormal thickening and enlargement of the heart muscle, particularly the walls of the chambers that pump blood, in response to increased workload or stress on the heart. It develops when the heart must work harder over time, most commonly as a result of chronic high blood pressure, which forces the left ventricle to contract against elevated resistance, but it can also arise from valve disease, certain inherited conditions, and other cardiovascular disorders. While some thickening can initially be a compensatory adaptation, sustained hypertrophy stiffens the heart, impairs its ability to fill and pump efficiently, and raises the risk of heart failure, arrhythmias, and other complications. Diagnosis relies on imaging such as echocardiography and on electrocardiography, and management centers on treating the underlying cause, especially controlling blood pressure, to halt or reverse the process. As a condition closely tied to hypertension and cardiac function, cardiac hypertrophy falls within the scope of Hypertension and Cardiology. Research relevant to the journal includes work on cardiorenal signaling pathways in heart failure, microRNAs in hypertension and ischemic heart disease, and cardiac and kidney remodeling in experimental hypertension, reflecting its coverage of the cardiovascular consequences of high blood pressure. This page gathers peer-reviewed, open-access research relevant to cardiac hypertrophy and hypertensive heart disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 18 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cardiac Hypertrophy, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hypertension and Cardiology (ISSN 2329-9487).

Journal editorial board
Hatori Nobuo · Japan Gregor Leibundgut · Switzerland Yuejin Li · United States

This page summarises published research for orientation; it is not medical or professional advice.