Intestinal Barrier Function

Intestinal barrier function is the role of the primarily single layer of cells that line the intestines. This barrier is responsible for regulating what passes in and out of the intestinal lumen. Composed of factors such as tight junctions, mucus, and the intestinal microbiome, this barrier is responsible for maintaining proper homeostasis while also shielding the body from toxins, allergens, and other potential pathogens. Its importance is highlighted in a range of diseases such as Crohn's disease, where its dysfunction leads to increased intestinal permeability and consequently, a more pronounced inflammatory response. Intestinal barrier function is therefore paramount for adequate health, to maintain proper immune response and to protect against infectious agents.