Rare Genetic Diseases

Rare genetic diseases (RGD) are a group of illnesses caused by an inherited genetic abnormality. They are usually caused by a single gene defect, and can affect any organ or system in the body. RGD may be more common than commonly thought, as 75% of all cases are caused by a single gene defect, and roughly 25-30% of cases are caused by two or more defects. Many of these conditions do not present typical signs or symptoms, and as such, they can be difficult to diagnose. Early diagnosis can be critical, as some of these conditions can have serious consequences if left untreated. Due to the wide range of symptoms, diagnosis is often done with genetic testing. Treatment of the disease is based on the specific symptoms and the extent of the condition. Management and treatment of these rare diseases relies heavily on genetic counseling and support, as well as medical and surgical interventions.

← Journal of Hereditary Diseases

Related Articles

68 article(s) found

Single Nucleotide Polymorphisms associated with alimentary fatty liver disease are not genetic risk factors for treatment-associated hepatic steatosis in HIV patients on HAART

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Genetic Polymorphisms in Patients with Epilepsy: A Mini Review.

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Autoimmune Diseases: Genes, Inflammation And Environment

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Molecular Cytogenetic Investigations in a Novel Chromosomal Abnormality of t(10;15)(q22;q22) in a Pediatric Precursor-B-Acute Lymphoblastic Leukemia Patient

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A Review of the Histologic, Genetic and Molecular Characteristics of Meningioma Pathogenesis and Progression

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An Extremely Rare Case of Thoracic Intramedullary Melanocytoma: Case Report and Review of Literature

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The Lower Prevalence of Chronic Diseases Risk Factors in Vegetarian Brazilians Subjects – CARVOS Study

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Pseudotumor Tuberculosis Of Liver: A Rare Entity

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Epigenetics and Nutrition

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Epidemiology and the Histopathological Pattern of Diagnosis of Thyroid Diseases in a University Hospital in Riyadh, Saudi Arabia

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A Rare Sellar Lesion: Pituitary Actinomyces Infection

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A Multidisciplinary Approach in The Diagnosis of Allergic and Non-Allergic Respiratory Diseases: Nasal Cytology and Feno.

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Factors Associated with Uncontrolled High Blood Pressure amongst patients with Hypertension at Harare Central Hospital in Zimbabwe

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Rare cause of gastric varices secondary to an isolated left gastric vein stenosis

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Pharmaceutical intervention on Ca2+/cAMP signaling interaction: benefits for combating neurodegeneration and diseases related to aging

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Rare Lipomatous Neoplasm of The Thigh in A 13 Year Old Male with A Discussion of Imaging Features and Differential Diagnosis of A Fatty Extremity Mass

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Rice Epigenetic Pathways: Great Genetic Variation and Implication for Rapid Rice Breeding

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Journal of Diseases

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Scientific and Technological Interventions for Attaining Precision in Plant Genetics and Breeding

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Endocrine Disrupting Chemicals: Epigenetic Relevance and Mechanisms

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Genetic Diversity of Large Japanese Field Mouse Apodemus speciosus Populations and Identification of their Food Plant Resources using DNA Barcoding in an Industrial Green Space

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Genetic Diversity, Phylogenetic Tree and Principal Component Analysis Based on Morpho-Metric Traits of Assam Chilli

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Epigenetic Biomarkers in Head and Neck Cancer 

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Synthesis and Analysis of Copper Neem (Azadirechta Indica) Soap-Nitro and Ethoxy Benzothiazole Complexes for Anti-Bacterial Activity Related with Skin Diseases

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The Current Immunoassays and Emerging Immunogenomic Approaches for Immunomonitoring Cancer and Infectious Diseases

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Long Non-Coding RNAs Emerging as Potential Epigenetic Biomarkers for Tobacco and/or Alcohol-Induced Head and Neck Cancer

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A Rare Variant of the Stafne Bone Cavity Localized to the Subcondylar Region of the Mandible: A Case Report with Review of the Literature

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Asymptomatic Embolization After Percutaneous Ostium Primum Atrial Septal Defect Closure: a Rare Complication

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A Rare Cause of Fever of Unknown Origin: Reverse Shapiro’s Syndrome

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Research Status and Application Prospect of Epigenetic Regulation of BDNF Gene Expression in Chronic Pain 

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Genetic-Mathematical Modelling of Mutational Processes in a Population

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Allele Based Inference on Evolution and Extinction; A Genetic Drift Approach

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Acute Peritonitis: A Rare Complication Revealing Intestinal Tuberculosis

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Role of Tie2, CD14, Angiopoietin as Angiogenetic Markers in Hepatocellular Carcinoma Complicating Hepatitis C Virus Infection

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A Rare Cause of Acute Renal Failure: Retroperitoneal Fibrosis

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Amino Acids and their Derivatives in Pathogenesis and Treatment of Liver Diseases

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Natural Selection in a Population is a Problem of Nonlinear Genetics

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The Genetic Multiplicity- Multiple Endocrine Neoplasia type I

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Pure Small Cell Carcinoma of Prostate in a Patient Presenting with Acute Urinary Retention: A Rare Case Report

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Evaluations of phylogenetic proximity in a group of 67 dogs with osteosarcoma: a pilot study

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The Intersection of Cultural Characteristics and Genetics on the Prevalence of Delayed Sleep Phase Syndrome in Brazilian and Japanese Adults

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Care in Chronic Diseases and in "Frail" Patients in General Practice

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Rare Association Between Neuroimmunological Diseases: A Possible Autoimmune Polyglandular Syndrome Type IV

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Genetic Algorithm Coupled with Neural Networks to Guesstimate the Subsurface Features of the Earth

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Genetic-Mathematical Modelling of the Populations Interaction

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Covid-19 Virus Sterilization Oven Based on Combination Between Ultraviolet and Infrared Emissions

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Some Regulation Mechanisms of Candidate Genes for Human Cardiovascular Diseases

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Proportion of WaterBorne Diseases in Children Aged 0 To 5 Years in the Health Area of the Urban Dispensary in Ebolowa - Cameroon

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Features of the Emergence and Re-Emergence of Infectious Diseases, Geopolitics and Gain-of-Function Research

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Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryo during Organogenesis and their Role as Epigenetics Regulators able to Reverse Neurosensory Hearing Loss

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Duodenocolic Fistula: A Rare Complication of Gastrointestinal Tuberculosis

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A Cancer Theory: The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

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Knowledge, Attitudes and Practices about Cardiovascular Diseases among Adult Patients Attending Public Health Centers in Kigali city, Rwanda

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Tay-Sachs Disease: From Molecular Characterization to Ethical Quandaries and the Possibility of Genetic Medicine

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Metastatic Malignant Melanoma of the Gastrointestinal Tract: A Rare Case and Review of Current Literature

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A Tandem of Rare Complications Due to Stent Infection

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Detection of Smuggled Genetically Modified Crops and Assessment of its Environmental Impact in the Ethio -Sudan Trans Boundary Area, North West Ethiopia

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Interventional Programs for Genetically Disabled People Through Evidence-Based Advocacy

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Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa

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Development of Municipal Decision-Making Strategies as Management Tools to Combat Waterborne Diseases

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Understanding Inherited Bleeding Disorders: Genetic Mutations in Blood Coagulation Factors and Regulatory Proteins

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Leflunomide-Induced Cystoid Macular Edema: A Rare Case Report

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Health-Related Quality of Life Perception Among Older Persons with Non-Communicable Diseases in Primary Healthcare Facilities: A Qualitative Inquiry

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Primary Healthcare Services and Health-Related Quality of Life of Older Persons with Non-Communicable Diseases: A Narrative Literature Review

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Why Do Human Body Systems Go Into Catastrophic System Failure Leading to Diseases -Is the Answer in Science or Nature?

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Comparative Study of Deep Learning Techniques for Detecting Corn Plant Leaf Diseases Using Transfer Learning

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Plasma TREM2 Levels, Alcohol Consumption, and Liver Enzymes in Patients with Alcohol use Disorder: A Sex-Dependent Relationship Involving MS4A6A Genetic Polymorphism

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Mathematical Modelling of Typhoid Fever Transmission Dynamics and Intervention Impact in Harare, Zimbabwe (2018–2020)

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