Research Topic · Peer-Reviewed

Sickle Cell Disease

Sickle cell disease is an inherited disorder of hemoglobin caused by a mutation in the beta-globin gene, which produces an abnormal hemoglobin that polymerizes when deoxygenated and distorts red blood cells into a rigid sickle shape. These cells obstruct small blood vessels and are prematurely destroyed, leading to …

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 40× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed June 2026

Overview

Sickle cell disease is an inherited disorder of hemoglobin caused by a mutation in the beta-globin gene, which produces an abnormal hemoglobin that polymerizes when deoxygenated and distorts red blood cells into a rigid sickle shape. These cells obstruct small blood vessels and are prematurely destroyed, leading to chronic hemolytic anemia, episodes of severe pain, organ damage, and increased vulnerability to complications. It is among the most common inherited blood disorders worldwide and a major focus of hematology. The articles gathered here address its clinical, hematological, and psychosocial dimensions. Disease manifestations and predictors feature in work on clinical and laboratory predictors of elevated tricuspid regurgitant velocity in sickle cell anemia, a marker of cardiopulmonary complication, and in a case of compound heterozygous hemoglobin SD presenting as crisis in pregnancy. Psychosocial and care-related aspects are examined through study of the relationship between depression and pain in women with the disease and a review of challenges and interventions to improve care in a high-burden setting. Related hematological and genetic conditions appear in work on thalassemia and physical activity, dengue-associated hematological disturbance, and advocacy for genetically disabled populations. Pregnancy-associated anemia is also considered. Together these contributions reflect the central concerns of sickle cell disease: understanding its hemoglobin-based mechanism, recognizing and predicting complications, and improving clinical and supportive care for affected individuals.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 10 articles above have been cited 40 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Sickle Cell Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.