Journal of Hematology and Oncology Research

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Hematology and Oncology Research-Interaction of coagulation and inflammation with special focus on virus infection.-Silvio Antoniak

United States

Division of Hematology/Oncology
McAllister Heart Institute
Department of Medicine
University of North Carolina at Chapel Hill


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Silvio Antoniak


Mary Ellen Jones Building Room 321
Campus Box #7035
Chapel Hill, NC 27599, United States.

Research Interests:

  • Interaction of coagulation and inflammation with special focus on virus infection.
  • Protease-activated receptors in cardiovascular diseases, myocarditis, and heart failure animal models.


  • MSc 2004 Humboldt University Berlin, Germany
  • PhD 2008 Free University Berlin, Germany
  • Postdoc 2008-2012 UNC at Chapel Hill
  • Research Associate 2012 UNC at Chapel Hill


  1. Tissue factor expression by the endothelium: Coagulation or inflammation?
  2. Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3-Induced Myocarditis.
  3. Viral myocarditis and coagulopathy: Increased tissue factor expression and plasma thrombogenicity.
  4. Tissue factor Deficiency Increases Alveolar Hemorrhage and Death in Influenza A Infected Mice.
  5. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines.
  6. Cdc2-Like Kinases and DNA Topoisomerase I Regulate Alternative Splicing of Tissue Factor in Human Endothelial Cells.
  7. Alternatively Spliced Tissue Factor and Full-length Tissue Factor Protect Cardiomyocytes against TNF-α-induced Apoptosis.
  8. Evaluation of a New Commercial Assay to Measure Microparticle Tissue Factor Activity in Plasma: communication from the SSC of the ISTH.
  9. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1 and KLF4 and decreased tissue factor.
  10. Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.