Research Topic · Peer-Reviewed

Follicular Lymphoma

Follicular lymphoma is an indolent, B-cell non-Hodgkin lymphoma that arises from germinal-centre B cells of the lymphoid follicle. It is defined histologically by a nodular (follicular) growth pattern composed of centrocytes and centroblasts, and molecularly by the hallmark t(14;18)(q32;q21) translocation, which jux…

Curated from this journal's research 📚 7 peer-reviewed articles cited Cited 13× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Follicular lymphoma is an indolent, B-cell non-Hodgkin lymphoma that arises from germinal-centre B cells of the lymphoid follicle. It is defined histologically by a nodular (follicular) growth pattern composed of centrocytes and centroblasts, and molecularly by the hallmark t(14;18)(q32;q21) translocation, which juxtaposes the BCL2 gene with the immunoglobulin heavy-chain locus and drives constitutive anti-apoptotic BCL2 expression. The neoplastic cells characteristically co-express CD20, CD10, and BCL6, reflecting their germinal-centre origin. Clinically the disease tends to present with painless, often widespread lymphadenopathy and bone-marrow involvement, following a relapsing-remitting course over many years; a subset undergoes histological transformation to an aggressive large B-cell lymphoma. Grading is based on the proportion of centroblasts per high-power field, and staging integrates nodal and extranodal spread. Diagnosis rests on excisional lymph-node biopsy with immunophenotyping and cytogenetic or molecular confirmation, distinguishing it from reactive follicular hyperplasia and other small B-cell lymphomas. Management ranges from active surveillance in low-burden disease to anti-CD20 immunotherapy combined with chemotherapy, radiotherapy for localised disease, and newer targeted agents. Research emphasises the tumour microenvironment, immune evasion, and prognostic indices that predict transformation and survival.

Research published in this journal

7 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 7 articles above have been cited 13 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Follicular Lymphoma, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.