Cyclophosphamide is a chemotherapy drug of the alkylating-agent class, widely used to treat cancers including haematological malignancies such as leukemia and lymphoma, as well as some solid tumours and certain autoimmune diseases. It works by adding alkyl groups to DNA, cross-linking the strands and preventing canc…
Cyclophosphamide is a chemotherapy drug of the alkylating-agent class, widely used to treat cancers including haematological malignancies such as leukemia and lymphoma, as well as some solid tumours and certain autoimmune diseases. It works by adding alkyl groups to DNA, cross-linking the strands and preventing cancer cells from replicating their genetic material, which halts their division and triggers cell death. Because it also affects healthy rapidly dividing cells, cyclophosphamide can cause side effects such as suppression of blood-cell production, increased infection risk, nausea, hair loss, and toxicity to the bladder and reproductive tissues. Research published in this journal addresses cyclophosphamide and the haematological and oncological settings in which it is used, including an experimental study showing that fennel oil protected against cyclophosphamide-induced impairment of spermatogenesis and oxidative stress in rats, which illustrates the drug's gonadal toxicity and efforts to mitigate it. Further work in the journal on lymphoma, stem-cell mobilization and transplantation, and the diagnosis of related blood disorders reflects the clinical context in which alkylating chemotherapy is applied. These studies illustrate both the therapeutic role and the toxicities of cyclophosphamide in cancer care. This page gathers peer-reviewed, open-access research relevant to cyclophosphamide and the treatment of haematological and oncological disease.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Cyclophosphamide, linking to each citing work.