Research Topic · Peer-Reviewed

Blood Coagulation

Blood coagulation, or hemostasis, is the tightly regulated physiological process by which circulating clotting factors, platelets, and the vascular endothelium interact to form a stable fibrin clot that arrests bleeding from an injured vessel. It proceeds in two coordinated phases. Primary hemostasis involves platel…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 36× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Blood coagulation, or hemostasis, is the tightly regulated physiological process by which circulating clotting factors, platelets, and the vascular endothelium interact to form a stable fibrin clot that arrests bleeding from an injured vessel. It proceeds in two coordinated phases. Primary hemostasis involves platelet adhesion, activation, and aggregation at the site of vascular damage, a process critically mediated by von Willebrand factor and modulated by its cleaving protease ADAMTS13. Secondary hemostasis comprises the coagulation cascade, a sequential proteolytic amplification in which clotting factors, initiated largely by tissue factor exposure, converge to generate thrombin and cross-linked fibrin. These procoagulant reactions are balanced by natural anticoagulant pathways and the fibrinolytic system, which restrict clot formation and ultimately dissolve it. Disruption of this equilibrium produces clinically important disorders at both extremes. Inherited deficiencies or mutations in coagulation factors and their regulatory proteins cause bleeding diatheses, including the classical hemophilias and factor XI deficiency (hemophilia C), as well as acquired forms. Conversely, hypercoagulable states arising in malignancies such as acute leukemia, in genetic polymorphisms affecting tissue factor, and in infections including dengue hemorrhagic fever, predispose to pathological thrombosis. Storage-related platelet apoptosis further illustrates how cellular viability shapes hemostatic competence.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2017

The antioxidant and hepatoprotective activities of two tea polysaccharides

Yu ZhiCorresponding author
College of Horticulture and Forestry Science, Huazhong Agricultural University, Key Laboratory of Horticultural Plant Biology, Ministry of Education, No. 1 Shizishan Street, Hongshan District, Wuhan City, Hubei Province, China 430070
Exact topic Antioxidant Activity Cited by 5 doi:10.14302/issn.2471-2140.jaa-17-1541

How this research is being cited

The 11 articles above have been cited 36 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Blood Coagulation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.