Beta-thalassemia

Beta-thalassemia is a genetic blood disorder that leads to anemia in individuals. It is caused by a mutation of the HBB gene, which leads to abnormal or insufficient production of beta-globin, a protein that is essential in the formation of hemoglobin. Hemoglobin is a crucial component of red blood cells and is responsible for carrying oxygen throughout the body. Beta-thalassemia is classified into two types: beta-thalassemia minor and beta-thalassemia major. Beta-thalassemia minor is a mild form of the disease that typically does not require treatment, while beta-thalassemia major is a severe form that can lead to a transfusion-dependent anemia. Beta-thalassemia is most common in individuals with Mediterranean, Middle Eastern, or Asian heritage. Diagnosis is typically made through blood tests, and treatment includes blood transfusions, iron chelation therapy, and bone marrow transplantation. Research in hematology and oncology on beta-thalassemia has led to advancements in understanding the genetic basis of the disease and potential treatments. Gene therapy, which involves the insertion of healthy genes into a patient's cells to replace mutated ones, has shown promise in treating beta-thalassemia. Additionally, research on the use of CRISPR-Cas9 gene editing technology to correct the HBB mutation shows potential for future treatments. In summary, beta-thalassemia is a genetic blood disorder that can lead to anemia in individuals. Hematology and oncology research on this disease has led to advancements in understanding its genetic basis and potential treatments such as gene therapy and CRISPR-Cas9 gene editing technology.


From: Hematology Research and Oncology Research

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Editor-in-chief: Krzysztof Roszkowski, Department of Oncology F. Lukaszczyk Oncology Center Nicolaus Copernicus University
Publication Type: Open Access Journal
Description: Hematology is a branch of medicine concerning the study of blood, the blood-forming organs, and blood diseases. The word "heme" comes from the Greek for blood. Oncology is a branch of medicine that deals with prevention, diagnosis and treatment of cancer. It is very important for oncologists to keep updated of the latest advancements in oncology.