Adenocarcinomas are malignant epithelial tumours that originate from glandular or secretory cells and frequently retain features of glandular differentiation, such as gland formation or mucin production. They constitute a major category of carcinoma and can arise in any organ containing glandular epithelium, includi…
Adenocarcinomas are malignant epithelial tumours that originate from glandular or secretory cells and frequently retain features of glandular differentiation, such as gland formation or mucin production. They constitute a major category of carcinoma and can arise in any organ containing glandular epithelium, including the lung, prostate, colon and rectum, pancreas, breast, stomach, and thyroid, with each site exhibiting distinct risk factors, molecular alterations, and clinical behaviour. Tumorigenesis typically proceeds through recognised precursor lesions and stepwise genetic and epigenetic changes; in the colorectum, for example, serrated lesions define an alternative pathway to carcinogenesis distinct from the conventional adenoma-carcinoma sequence. Adenocarcinomas vary in differentiation and aggressiveness, and their invasive and metastatic potential reflects the progressive loss of glandular architecture and acquisition of motility and stromal-remodelling capabilities. Diagnosis relies on histopathology, immunohistochemistry, and molecular markers that establish the tissue of origin and guide therapy, while biomarker discovery and trace-element analyses of tumour tissue, including studies of elemental content in prostate and thyroid neoplasia, contribute to the characterisation of these malignancies. Research on adenocarcinomas addresses the molecular pathways underlying their initiation and progression, the identification of diagnostic and prognostic biomarkers, and the refinement of surgical, systemic, and immune-based treatments across the diverse anatomical sites in which glandular cancers occur.
6 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 6 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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