Citrullination

Citrullination is a post-translational modification (PTM) of proteins, in which an arginine amino acid is converted into a citrulline amino acid. This process is important for protein function and plays a key role in several important biological processes such as gene expression, cell signaling, and immunological response. It has been linked to a number of pathologies, including autoimmune diseases, cancer, and Alzheimer's disease, thus making its study an important field of research. Citrullination has also been used to identify novel biomarkers for diagnosis and prognosis, and as a tool to improve the understanding of pathogenesis.