Microhomology-Mediated End Joining

Microhomology-mediated end joining (MMEJ) is a type of genetic engineering technique used to repair double-strand breaks in the genome. It works by using short stretches of homologous sequences (known as microhomology) to fuse two strands of DNA together. MMEJ is important in gene therapy, allowing the correction of mutations in a patient’s genome, and in the production of genetically modified organisms. It is also used to study genetic diseases in model organisms and more generally, to understand the roles of different genes. MMEJ is a powerful tool for manipulating the genome and can be used for many different applications.