Gene Disruption

Gene disruption is a technique used to alter the functioning of a gene in an organism. It involves using methods such as mutagenesis, homologous recombination, or CRISPR technology to disrupt a gene's normal sequence of DNA or RNA, which then prevents the gene from being translated into a functional protein. Gene disruption is significant in that it allows scientists to study the effects of specific genes in an organism, and how these genes interact with other genes or the environment. This knowledge can then be used to better understand phenomena such as genetic diseases and evolutionary processes. Additionally, this technique can be used in gene therapy as a way to correct genetic defects and/or to introduce functional proteins into cells.

← Journal of Genetic Engineering

Related Articles

103 article(s) found

Evolutionary Conservation of Hox Genes in Vertebrate Brain Development

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Single Nucleotide Polymorphisms associated with alimentary fatty liver disease are not genetic risk factors for treatment-associated hepatic steatosis in HIV patients on HAART

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Genetic Polymorphisms in Patients with Epilepsy: A Mini Review.

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Autoimmune Diseases: Genes, Inflammation And Environment

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Evaluating the Efficacy of Gene Silencing in Dopaminergic Neuronal Cells In-Vitro using Gold Nanorods (GNR) with Different Surface Properties Complexed to DARPP-32 siRNA.

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Molecular Cytogenetic Investigations in a Novel Chromosomal Abnormality of t(10;15)(q22;q22) in a Pediatric Precursor-B-Acute Lymphoblastic Leukemia Patient

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A Review of the Histologic, Genetic and Molecular Characteristics of Meningioma Pathogenesis and Progression

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Mechanisms Associated with Acquisition of Resistance to Butyrate-Induced Apoptosis in Colorectal Cancer Cells Using Gene Expression Analysis

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Serrated Lesions of Colorectum: A New Pathway in Colorectal Carcinogenesis

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Haematological Disturbances in Dengue Haemorrhagic Fever - its Pathogenesis and Management Perspectives

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Epigenetics and Nutrition

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Anti-Oxidant Phytochemicals as Potential Treatments for Age-Related Macular Degeneration

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MicroRNA-1285 Might Potentially Regulate OCT4 Gene Expression by Direct Targeting of its Promoter

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Investigations of Molecular Evolutionary Mechanisms in Partially Sequenced Heat Shock Protein70 Homologue-Coding Gene of Olive Leaf Yellowing-Associated Virus Isolates from Tunisia

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The Role of BCL-2 and BAK Genes in Chronic Kidney Disease and Haemodialysis Patients

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Gene-Eden-VIR: A Potential Natural Treatment for Cervical Cancer

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A study on the association of ACE i/D gene polymorphism, Obesity, Blood pressure and susceptibility of type 2 diabetes mellitus among the Kurmis of West Bengal, India.

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Immune Thrombocytopenia after Allogeneic Stem Cell Transplantation: Case Report and Brief Overview of Treatment Strategies

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Fast Screening Method for Polymorphisms in Exon 9 of the Catalase Gene.

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Emerging Paradigms in Regenerative Medicine: Stem cell Therapies

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Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis

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Dual Effects of Neuroprotection and Neurotoxicity by General Anesthetics on Neural Stem Cells: Role of Autophagy

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Rescuing Canavan Disease by Redirecting Metabolic Processing: Support for the Astrocyte Hypothesis of Canavan Disease Generation and A Possible Human Cure

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Protective Effect of Fennel Oil on Cyclophosphamide Inhibited Spermatogenesis and Induced Oxidative Stress in Albino Rats.

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Embryogenesis and Applications of Fingerprints- a review

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Pharmaceutical intervention on Ca2+/cAMP signaling interaction: benefits for combating neurodegeneration and diseases related to aging

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Study of VCAM-1 Gene Expression in Normal and Tumoral Tissues in Patients with Colorectal Cancer

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Identification and Expression Analysis of Fragaria Vesca MLO Genes Involved in Interaction with Powdery Mildew (Podosphaera Aphanis)

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Spatial Heterogeneity of Soil Respiration Response to Precipitation Pulse in a Temperate Mixed Forest in Central China

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Rice Epigenetic Pathways: Great Genetic Variation and Implication for Rapid Rice Breeding

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Study of Neuropilin-1/Cd304 Expression in Leukemogenesis

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General Evolution of the Universe Driven by Attraction and Four Levels of Biological Evolution as its Essential Part

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Successful Allogeneic Hematopoietic Stem Cell Transplantation from A 5/10 Mismatched Unrelated Donor in A Patient with Donor-Specific Anti-HLA Antibodies.

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Bisphenol A Down-Regulates The mRNA Expression of Steroidogenic Genes and Induces Histopathological Changes in Testes Of Rats

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Scientific and Technological Interventions for Attaining Precision in Plant Genetics and Breeding

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The Effect of Laser Irradiation on Reparative Osteogenesis

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Current Status and Future Perspectives of Gene Therapy for Heart Failure

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Endocrine Disrupting Chemicals: Epigenetic Relevance and Mechanisms

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Genetic Diversity of Large Japanese Field Mouse Apodemus speciosus Populations and Identification of their Food Plant Resources using DNA Barcoding in an Industrial Green Space

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The Development and Evaluation of A Multiplex Real-Time PCR Assay for the Detection of ESBL Genes in Urinary Tract Infections

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Looking for the Best Journey: Real Methodology of Research in General Medicine

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Is the Measles Virus Indeed Involved in Carcinogenesis? – Commentary

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Method to Generate Electric Power and Hydrogen in the Absence Of External Energy

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Genetic Diversity, Phylogenetic Tree and Principal Component Analysis Based on Morpho-Metric Traits of Assam Chilli

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"The 11 +" Warm-Up Program in Female Soccer Players and the Morpho-Physiological Changes Generated after its Implementation

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Epigenetic Biomarkers in Head and Neck Cancer 

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Long Non-Coding RNAs Emerging as Potential Epigenetic Biomarkers for Tobacco and/or Alcohol-Induced Head and Neck Cancer

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Consequences of Repression of Emotion: Physical Health, Mental Health and General Well Being

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Ontogenes and the Problem of Speciation

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D Allele and DD Genotype of I /D Polymorphism in The ACE Gene in Patients with Hypertension, Stroke And Cancer Prostate In Libreville: A Concern Given The High Frequencies of these Signatures in Gabonese Population

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Research Status and Application Prospect of Epigenetic Regulation of BDNF Gene Expression in Chronic Pain 

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L162v Polymorphism of Par-Α Gene, A603g Polymorphism of Tissue Factor Gene and Risk of Coronary Heart Disease in Russian Population

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Characterization of rpoB Gene Mutations Associated with Rifampicin Resistance in Multidrug Resistant Tuberculosis Patients Co-infected with HIV from Southern India.

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Genetic-Mathematical Modelling of Mutational Processes in a Population

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Allele Based Inference on Evolution and Extinction; A Genetic Drift Approach

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Type-2 Diabetes and Gene Therapy: The Promise of CRISPR Gene Therapy in type-2 Diabetes Mellitus

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Non-Enzymatic Methylglyoxal Formation From glucose Metabolites and Generation of Superoxide Anion Radical During Methylglyoxal-Dependent Cross-Links Reaction

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Molecular and Metabolic Pathogenesis of Familial Combined Hyperlipidemia and Association with Metabolic Syndrome

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Genes in Tumor Formation

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Role of Tie2, CD14, Angiopoietin as Angiogenetic Markers in Hepatocellular Carcinoma Complicating Hepatitis C Virus Infection

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Amino Acids and their Derivatives in Pathogenesis and Treatment of Liver Diseases

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Natural Selection in a Population is a Problem of Nonlinear Genetics

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The Genetic Multiplicity- Multiple Endocrine Neoplasia type I

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Evaluations of phylogenetic proximity in a group of 67 dogs with osteosarcoma: a pilot study

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Association of BsmI and ApaI Polymorphisms of the Vitamin D Receptor Gene with Dyslipidemia in Patients with Coronary Artery Disease.

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Practical Methods to Improve Client Compliance in General Medicine

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The Mechanism of Decline of Senescent Skeletal Muscle Satellite Cell Self-Renewal and Regenerative Proliferation: The Role of Heparan Sulfate-FGF-2--FGFR1-p38αMAPK Axis, Sprouty1, miR-1, miR-133 and miR-29a

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The Intersection of Cultural Characteristics and Genetics on the Prevalence of Delayed Sleep Phase Syndrome in Brazilian and Japanese Adults

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Care in Chronic Diseases and in "Frail" Patients in General Practice

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Patient Safety and Clinical Risk Management for General Practice

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General Doctor's Consultation Work Begins before Entering the Patient and does not End when Patient Comes Out

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Molecular Study of Hepcidin HAMP (-582A/G) Gene Polymorphisms and Measurement of Serum Hepcidin Level among Sudanese Patients with Anemia of Chronic Kidney Disease

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Laboratory Tests Used in the Diagnosis of Immune Thrombocytopenia and General Treatment Approaches

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Molecular Analysis of 6-pyruvoyltetrahydropterin Synthase Gene in Atypical Phenylketonuric Egyptian Patients

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Genetic Algorithm Coupled with Neural Networks to Guesstimate the Subsurface Features of the Earth

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Rate, Maternal and Fetal Outcome of Cesarean Delivery Performed by IESO at Shenen Gibe General Hospital, Jimma South West Ethiopia: A Descriptive Retrospective Data

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Genetic-Mathematical Modelling of the Populations Interaction

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Effect of Hydroxychloroquine on Clinical Improvement and Mortality Among Patients with COVID-19 Admitted to Four General Hospitals in Saudi Arabia

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Exponential Parsimony to Generate Herd Immunity Against SARS- CoV2 Cybernetically Restricting Doxastic and Desiderative Logics

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Molecular Evolutionary Characteristics of the 2019 Novel Coronavirus (SARS-CoV-2) Contracted by Tunisian Citizens : Comparison and Relationship to Other Human and Animal Coronaviruses Based on Spike Glycoprotein-Coding Gene Sequences Analysis

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Some Regulation Mechanisms of Candidate Genes for Human Cardiovascular Diseases

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Generation of a Single-Domain Antibody against Isolated Escherichia Coli that Causes Camel-Calf Death

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A New Gene Mutation of PRKAR1A was found in a Carney Complex Case

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Exponential Parsimony to Generate Herd Immunity Against SARS- CoV2 Cybernetically Restricting Doxastic and Desiderative Logics

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Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryo during Organogenesis and their Role as Epigenetics Regulators able to Reverse Neurosensory Hearing Loss

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Tay-Sachs Disease: From Molecular Characterization to Ethical Quandaries and the Possibility of Genetic Medicine

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Marginal SARS-CoV-2 Spike Protein Increases Interferon and Balances Cytokine Gene Expression

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Detection of Smuggled Genetically Modified Crops and Assessment of its Environmental Impact in the Ethio -Sudan Trans Boundary Area, North West Ethiopia

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A General Approach to Modeling Covid-19

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Interventional Programs for Genetically Disabled People Through Evidence-Based Advocacy

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Barriers to Managing Childhood Obesity in the General Practice Amidst of the Double Burden of Malnutrition: A Sri Lankan Perspective

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A Trio Study Showing Novel Gene Mutation In LAMB3 Causing Junctional Epidermolysis Bullosa (Intermediate/ Severe)

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Novel Methods for Inhibiting Amyloidogenesis in the Presence of Peptides to Block Hydrophobic Interactions

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Ontogenes in Drosophila Melanogaster and a Model of Speciation

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Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa

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Understanding Inherited Bleeding Disorders: Genetic Mutations in Blood Coagulation Factors and Regulatory Proteins

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Disruption of Hydrogen Bonding Network Decreases Catalytic Diversity of Chloroperoxidase via Abolishing Both Chlorination and Dismutation Activities

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Plasma TREM2 Levels, Alcohol Consumption, and Liver Enzymes in Patients with Alcohol use Disorder: A Sex-Dependent Relationship Involving MS4A6A Genetic Polymorphism

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The Brainstem Auditory Evoked Potential: A Reinterpretation of its Electrogenesis

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Persistent Neovascular Exudation in Patients with Exudative Age-Related Macular Degeneration who have Choroid Imaging Biomarkers of Non-Neovascular Choroidal Pathology: Simultaneous Choroidal Hyperpermeability and Angiogenesis

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To Achieve High-Quality Agricultural Development is the General Trend of the Times

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Review: The Role of Human Papillomavirus in Virus-Induced Carcinogenesis

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Lineage-Specific Disruption of Hematopoiesis by Oxaliplatin: Mechanisms of Erythropoietin Resistance and Immune Suppression

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