Base Excision Repair
Base Excision Repair (BER) is a cellular process used to repair damaged DNA. It is the most abundant and important DNA repair mechanism and is employed to maintain the integrity of an organism’s genetic material. BER is important for the repair of single nucleotide changes (such as point mutations) and the removal of various types of DNA lesions, including alkylating agents, deamination, and oxidation of bases. It also works to repair damage to DNA caused by ultraviolet radiation, and is an important factor in the prevention of carcinogenic mutations. BER is critical for the preservation of cellular and organismal health, and defects in BER pathways are associated with an increased risk of cancer.
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