Serine-Threonine Kinases

Serine-Threonine Kinases (STKs) are a family of enzymes that play a key role in regulating the cell cycle, cell growth, and cellular responses to external signals. These enzymes act as signal integrators, catalyzing the transfer of phosphate to serine or threonine residues on proteins to regulate their functions. By doing so, STKs are involved in a wide range of biological processes including proliferation, differentiation, migration, metabolism, stress response and apoptosis. Therefore, they are key players in several diseases such as cancer, diabetes and neurological disorders, thus representing potential drug targets. The development of potent and specific inhibitors of STKs has provided promising treatments for these diseases.